Collagen Scaffolds in Bone Sialoprotein-Mediated Bone Regeneration
Joint Authors
Kruger, Thomas E.
Miller, Andrew H.
Wang, Jinxi
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-31
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Decades of research in bioengineering have resulted in the development of many types of 3-dimentional (3D) scaffolds for use as drug delivery systems (DDS) and for tissue regeneration.
Scaffolds may be comprised of different natural fibers and synthetic polymers as well as ceramics in order to exert the most beneficial attributes including biocompatibility, biodegradability, structural integrity, cell infiltration and attachment, and neovascularization.
Type I collagen scaffolds meet most of these criteria.
In addition, type I collagen binds integrins through RGD and non-RGD sites which facilitates cell migration, attachment, and proliferation.
Type I collagen scaffolds can be used for bone tissue repair when they are coated with osteogenic proteins such as bone morphogenic protein (BMP) and bone sialoprotein (BSP).
BSP, a small integrin-binding ligand N-linked glycoprotein (SIBLING), has osteogenic properties and plays an essential role in bone formation.
BSP also mediates mineral deposition, binds type I collagen with high affinity, and binds αvβ3 and αvβ5 integrins which mediate cell signaling.
This paper reviews the emerging evidence demonstrating the efficacy of BSP-collagen scaffolds in bone regeneration.
American Psychological Association (APA)
Kruger, Thomas E.& Miller, Andrew H.& Wang, Jinxi. 2013. Collagen Scaffolds in Bone Sialoprotein-Mediated Bone Regeneration. The Scientific World Journal،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1012927
Modern Language Association (MLA)
Kruger, Thomas E.…[et al.]. Collagen Scaffolds in Bone Sialoprotein-Mediated Bone Regeneration. The Scientific World Journal No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-1012927
American Medical Association (AMA)
Kruger, Thomas E.& Miller, Andrew H.& Wang, Jinxi. Collagen Scaffolds in Bone Sialoprotein-Mediated Bone Regeneration. The Scientific World Journal. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1012927
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1012927