Effect of deltamethrin on the liver and kidney functions in rats
Joint Authors
Aziz, Majda A.
al-Shadhili, K. A.
Ali, F. R.
Wahhab, T. M. A.
Taha, Manal M. A. M.
Source
Kafr El-Sheikh Veterinary Medical Journal
Issue
Vol. 2, Issue 1 (30 Apr. 2004), pp.227-238, 12 p.
Publisher
Kafr El-Sheikh University Faculty of Veterinary Medicine
Publication Date
2004-04-30
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Topics
Abstract EN
The present study was designed to determine the toxic effects of deltam-ethrin (DT) at dose level of 0.12, 0.06 mg / kg b.
w.
administered daily by oral route for 5 weeks on some biochemical parameters of male Albino rats including liver and kidney function tests, blood picture and histopathologically picture of the liver and kidney.
The study revealed that rats treated with both doses of deltamethrin showed a significant decrease in serum total protein (TP), serum albumin and serum globulin (G) and a significant increase in serum aspartate aminotransferase (AST), serum alanine aminotransferase (ALT) and alkaline phosphatase activity.
The hematological parameters, RBCs showed a significant increase while there was a significant decrease in HB content with a marked microcytic hypochromic anemia which was indicated by low mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH) and mean corpuscular hemoglobin concentration (MCHC).
A marked increase in WBCs count specially in neutrophils were observed while there was a marked decrease in lymphocytes The histopathologically picture revealed that there was a severe conge-stion of the portal blood vessels, massive infiltration of portal area with lymphocytes and pressure atrophy of hepatocytes with psychotic nuclei while the kidney showed congestion of intertubular blood vessels.
American Psychological Association (APA)
Aziz, Majda A.& Ali, F. R.& Wahhab, T. M. A.& al-Shadhili, K. A.& Taha, Manal M. A. M.. 2004. Effect of deltamethrin on the liver and kidney functions in rats. Kafr El-Sheikh Veterinary Medical Journal،Vol. 2, no. 1, pp.227-238.
https://search.emarefa.net/detail/BIM-101305
Modern Language Association (MLA)
Aziz, Majda A.…[et al.]. Effect of deltamethrin on the liver and kidney functions in rats. Kafr El-Sheikh Veterinary Medical Journal Vol. 2, no. 1 (2004), pp.227-238.
https://search.emarefa.net/detail/BIM-101305
American Medical Association (AMA)
Aziz, Majda A.& Ali, F. R.& Wahhab, T. M. A.& al-Shadhili, K. A.& Taha, Manal M. A. M.. Effect of deltamethrin on the liver and kidney functions in rats. Kafr El-Sheikh Veterinary Medical Journal. 2004. Vol. 2, no. 1, pp.227-238.
https://search.emarefa.net/detail/BIM-101305
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 236-238
Record ID
BIM-101305