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Evaluation of the Antibacterial and Antifungal Potential of Peltophorum africanum: Toxicological Effect on Human Chang Liver Cell Line
Joint Authors
Ndip, Roland N.
Okeleye, Benjamin I.
Mkwetshana, Noxolo T.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-11
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
We assessed the in vitro antimicrobial activity of Peltophorum africanum by means of the agar well and macrodilution methods.
The toxicity on a normal human liver cell (Chang liver cell) was determined using the CellTiter-Blue cell viability assay, and the compounds contained in the fractions were identified using GC-MS.
Zone diameter of inhibition of the extract ranged from 12.5±0.7 to 32 ± 2.8 mm for bacteria and from 7.5 ± 0.7 to 26.4 ± 3.4 mm for yeast.
Marked activity of the extract was observed against Plesiomonas shigelloides ATCC 51903, with MIC and MLC values of 0.15625 and 0.3125 mg/mL, respectively.
The extract was both bactericidal (MICindex≤2) and bacteriostatic/fungistatic (MICindex>2) in activity.
Lethal dose at 50 (LD50) showed 82.64±1.40 degree of toxicity at 24 hrs, and 95 percentile of cell death dose activity ranged from log 3.12±0.01 to 4.59±0.03.
The activity of the eight fractions tested ranged from 1.0±0.5 to 3.7±1.6 mg/mL (IC50) and from 2.1±0.8 to 6.25±0 mg/mL (IC90).
The extract was toxic to human Chang liver cell lines.
American Psychological Association (APA)
Okeleye, Benjamin I.& Mkwetshana, Noxolo T.& Ndip, Roland N.. 2013. Evaluation of the Antibacterial and Antifungal Potential of Peltophorum africanum: Toxicological Effect on Human Chang Liver Cell Line. The Scientific World Journal،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1013080
Modern Language Association (MLA)
Okeleye, Benjamin I.…[et al.]. Evaluation of the Antibacterial and Antifungal Potential of Peltophorum africanum: Toxicological Effect on Human Chang Liver Cell Line. The Scientific World Journal No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1013080
American Medical Association (AMA)
Okeleye, Benjamin I.& Mkwetshana, Noxolo T.& Ndip, Roland N.. Evaluation of the Antibacterial and Antifungal Potential of Peltophorum africanum: Toxicological Effect on Human Chang Liver Cell Line. The Scientific World Journal. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1013080
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1013080