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Association of nNOS Gene Polymorphism with Ischemic Stroke in Han Chinese of North China
Joint Authors
Dai, Yingjie
He, Zhiyi
Sui, Rubo
Jiang, Zhilin
Ma, Shanshan
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-03
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Nitric oxide (NO) is an important messenger molecule and effector molecule.
This study aimed to investigate the relation of neuronal nitric oxide synthase (nNOS) gene polymorphism with ischemic stroke in Han Chinese of North China.
This was a case-control study.
A total of 413 patients with ischemic stroke were recruited from Han Chinese of North China.
There were 201 males and 212 females.
In addition, 477 healthy subjects served as controls including 224 males and 253 females.
Multiplex SNaPshot was employed to detect nNOS gene polymorphism (rs2293050, rs2139733, rs7308402, and rs1483757).
Results showed that the rs1483757, rs2139733, and rs2293050 genotypes and allele frequencies were comparable between patients and controls.
However, ischemic stroke patients had significantly reduced AG genotype and A allele frequency when compared with controls (P=0.037, P=0.041).
After adjusting confounding factors (gender, age, smoking, history of drinking, hypertension, and diabetes), AG genotype and A allele were still related to ischemic stroke (OR=0.572, 95% CI: 0.335–0.978, P=0.041; OR=0.611, 95% C: 0.378–0.985, and P=0.041) and both were found to be protective factors.
Our results showed that rs7308402 gene polymorphism of nNOS is related to ischemic stroke in Han Chinese of North China.
American Psychological Association (APA)
Dai, Yingjie& He, Zhiyi& Sui, Rubo& Jiang, Zhilin& Ma, Shanshan. 2013. Association of nNOS Gene Polymorphism with Ischemic Stroke in Han Chinese of North China. The Scientific World Journal،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1013089
Modern Language Association (MLA)
Dai, Yingjie…[et al.]. Association of nNOS Gene Polymorphism with Ischemic Stroke in Han Chinese of North China. The Scientific World Journal No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1013089
American Medical Association (AMA)
Dai, Yingjie& He, Zhiyi& Sui, Rubo& Jiang, Zhilin& Ma, Shanshan. Association of nNOS Gene Polymorphism with Ischemic Stroke in Han Chinese of North China. The Scientific World Journal. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1013089
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1013089