Cholesterol Induces Uneven Curvature of Asymmetric Lipid Bilayers
Joint Authors
Yesylevskyy, S. O.
Demchenko, A. P.
Kraszewski, S.
Ramseyer, C.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-16
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
A remarkable flexibility is observed in biological membranes, which allows them to form the structures of different curvatures.
We addressed the question of intrinsic ability of phospholipid membranes to form highly curved structures and the role of cholesterol in this process.
The distribution of cholesterol in the highly curved asymmetric DOPC/DOPS lipid bilayer was investigated by the coarse-grained molecular dynamics simulations in the membrane patches with large aspect ratio.
It is shown that cholesterol induces uneven membrane curvature promoting the formation of extended flattened regions of the membrane interleaved by sharp bends.
It is shown that the affinity of cholesterol to anionic DOPS or neutral DOPC lipids is curvature dependent.
The cholesterol prefers DOPS to DOPC in either planar or highly curved parts of the membrane.
In contrast, in the narrow interval of moderate membrane curvatures this preference is inverted.
Our data suggest that there is a complex self-consistent interplay between the membrane curvature and cholesterol distribution in the asymmetric lipid bilayers.
The suggested new function of cholesterol may have a biological relevance.
American Psychological Association (APA)
Yesylevskyy, S. O.& Demchenko, A. P.& Kraszewski, S.& Ramseyer, C.. 2013. Cholesterol Induces Uneven Curvature of Asymmetric Lipid Bilayers. The Scientific World Journal،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1013241
Modern Language Association (MLA)
Yesylevskyy, S. O.…[et al.]. Cholesterol Induces Uneven Curvature of Asymmetric Lipid Bilayers. The Scientific World Journal No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-1013241
American Medical Association (AMA)
Yesylevskyy, S. O.& Demchenko, A. P.& Kraszewski, S.& Ramseyer, C.. Cholesterol Induces Uneven Curvature of Asymmetric Lipid Bilayers. The Scientific World Journal. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1013241
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1013241