Molecular Imaging of Experimental Abdominal Aortic Aneurysms
Joint Authors
Ramaswamy, Aneesh K.
Hamilton, Mark
Joshi, Rucha V.
Kline, Benjamin P.
Li, Rui
Wang, Pu
Goergen, Craig J.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-23
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Current laboratory research in the field of abdominal aortic aneurysm (AAA) disease often utilizes small animal experimental models induced by genetic manipulation or chemical application.
This has led to the use and development of multiple high-resolution molecular imaging modalities capable of tracking disease progression, quantifying the role of inflammation, and evaluating the effects of potential therapeutics.
In vivo imaging reduces the number of research animals used, provides molecular and cellular information, and allows for longitudinal studies, a necessity when tracking vessel expansion in a single animal.
This review outlines developments of both established and emerging molecular imaging techniques used to study AAA disease.
Beyond the typical modalities used for anatomical imaging, which include ultrasound (US) and computed tomography (CT), previous molecular imaging efforts have used magnetic resonance (MR), near-infrared fluorescence (NIRF), bioluminescence, single-photon emission computed tomography (SPECT), and positron emission tomography (PET).
Mouse and rat AAA models will hopefully provide insight into potential disease mechanisms, and the development of advanced molecular imaging techniques, if clinically useful, may have translational potential.
These efforts could help improve the management of aneurysms and better evaluate the therapeutic potential of new treatments for human AAA disease.
American Psychological Association (APA)
Ramaswamy, Aneesh K.& Hamilton, Mark& Joshi, Rucha V.& Kline, Benjamin P.& Li, Rui& Wang, Pu…[et al.]. 2013. Molecular Imaging of Experimental Abdominal Aortic Aneurysms. The Scientific World Journal،Vol. 2013, no. 2013, pp.1-18.
https://search.emarefa.net/detail/BIM-1013254
Modern Language Association (MLA)
Ramaswamy, Aneesh K.…[et al.]. Molecular Imaging of Experimental Abdominal Aortic Aneurysms. The Scientific World Journal No. 2013 (2013), pp.1-18.
https://search.emarefa.net/detail/BIM-1013254
American Medical Association (AMA)
Ramaswamy, Aneesh K.& Hamilton, Mark& Joshi, Rucha V.& Kline, Benjamin P.& Li, Rui& Wang, Pu…[et al.]. Molecular Imaging of Experimental Abdominal Aortic Aneurysms. The Scientific World Journal. 2013. Vol. 2013, no. 2013, pp.1-18.
https://search.emarefa.net/detail/BIM-1013254
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1013254