Arzanol, a Potent mPGES-1 Inhibitor: Novel Anti-Inflammatory Agent
Joint Authors
Kothavade, Pankaj S.
Nagmoti, Dnyaneshwar M.
Bulani, Vipin D.
Juvekar, Archana R.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-01
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Arzanol is a novel phloroglucinol α-pyrone, isolated from a Mediterranean plant Helichrysum italicum (Roth) Don ssp.
microphyllum which belongs to the family Asteraceae.
Arzanol has been reported to possess a variety of pharmacological activities.
However, anti-inflammatory, anti-HIV, and antioxidant activities have been studied in some detail.
Arzanol has been reported to inhibit inflammatory transcription factor NFκB activation, HIV replication in T cells, releases of IL-1β, IL-6, IL-8, and TNF-α, and biosynthesis of PGE2 by potentially inhibiting mPGES-1 enzyme.
Diversity of mechanisms of actions of arzanol may be useful in treatment of disease involving these inflammatory mediators such as autoimmune diseases and cancer.
This review presents comprehensive information on the chemistry, structure-activity relationship, and pharmacological activities of arzanol.
In addition this review discusses recent developments and the scope for future research in these aspects.
American Psychological Association (APA)
Kothavade, Pankaj S.& Nagmoti, Dnyaneshwar M.& Bulani, Vipin D.& Juvekar, Archana R.. 2013. Arzanol, a Potent mPGES-1 Inhibitor: Novel Anti-Inflammatory Agent. The Scientific World Journal،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1013273
Modern Language Association (MLA)
Kothavade, Pankaj S.…[et al.]. Arzanol, a Potent mPGES-1 Inhibitor: Novel Anti-Inflammatory Agent. The Scientific World Journal No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1013273
American Medical Association (AMA)
Kothavade, Pankaj S.& Nagmoti, Dnyaneshwar M.& Bulani, Vipin D.& Juvekar, Archana R.. Arzanol, a Potent mPGES-1 Inhibitor: Novel Anti-Inflammatory Agent. The Scientific World Journal. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1013273
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1013273