Arzanol, a Potent mPGES-1 Inhibitor: Novel Anti-Inflammatory Agent

Joint Authors

Kothavade, Pankaj S.
Nagmoti, Dnyaneshwar M.
Bulani, Vipin D.
Juvekar, Archana R.

Source

The Scientific World Journal

Issue

Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2013-10-01

Country of Publication

Egypt

No. of Pages

9

Main Subjects

Medicine
Information Technology and Computer Science

Abstract EN

Arzanol is a novel phloroglucinol α-pyrone, isolated from a Mediterranean plant Helichrysum italicum (Roth) Don ssp.

microphyllum which belongs to the family Asteraceae.

Arzanol has been reported to possess a variety of pharmacological activities.

However, anti-inflammatory, anti-HIV, and antioxidant activities have been studied in some detail.

Arzanol has been reported to inhibit inflammatory transcription factor NFκB activation, HIV replication in T cells, releases of IL-1β, IL-6, IL-8, and TNF-α, and biosynthesis of PGE2 by potentially inhibiting mPGES-1 enzyme.

Diversity of mechanisms of actions of arzanol may be useful in treatment of disease involving these inflammatory mediators such as autoimmune diseases and cancer.

This review presents comprehensive information on the chemistry, structure-activity relationship, and pharmacological activities of arzanol.

In addition this review discusses recent developments and the scope for future research in these aspects.

American Psychological Association (APA)

Kothavade, Pankaj S.& Nagmoti, Dnyaneshwar M.& Bulani, Vipin D.& Juvekar, Archana R.. 2013. Arzanol, a Potent mPGES-1 Inhibitor: Novel Anti-Inflammatory Agent. The Scientific World Journal،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1013273

Modern Language Association (MLA)

Kothavade, Pankaj S.…[et al.]. Arzanol, a Potent mPGES-1 Inhibitor: Novel Anti-Inflammatory Agent. The Scientific World Journal No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1013273

American Medical Association (AMA)

Kothavade, Pankaj S.& Nagmoti, Dnyaneshwar M.& Bulani, Vipin D.& Juvekar, Archana R.. Arzanol, a Potent mPGES-1 Inhibitor: Novel Anti-Inflammatory Agent. The Scientific World Journal. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1013273

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1013273