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Prognostic Efficacy of Nuclear Morphometry at Invasive Front of Oral Squamous Cell Carcinoma: An Image Analysis Microscopic Study
Joint Authors
Vedam, V. K. Vaishnavi
Boaz, Karen
Natarajan, Srikant
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-11-19
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Oral cancer is revisited on a pathologist perspective with advanced imaging technique.
Objective.
The present study assessed the new malignancy grading system at tumor proper (TP) and Bryne’s grading system at invasive tumor front (ITF), morphometric features using software, to clarify their associations with prognosis of oral cancers.
Methods.
Histologically confirmed oral squamous cell carcinoma (OSCC) with 5-year follow-up was assessed morphometrically using image analysis at TP and ITF, correlated with the prognosis of patient.
Results.
On comparison of grading systems, a moderate agreement between both (Bryne and Anneroth) was seen.
Among all histological parameters, we noted inverse correlation between degree of mitosis at invasive front and decrease in lymphoplasmacytic infiltrate at ITF with increase rate of recurrence and event of death.
An increase in nuclear area, diameter, and perimeter along with decrease circularity in advancing OSCC was seen.
Correlation of parameters showed higher values for maximum nuclear diameter, perimeter, and circularity at TP and ITF with recurrence.
Conclusion.
This study, while limited in sample size, concluded that a combined assessment of clinical TNM staging, histopathological grading system { excluding the parameter “mitotic activity” (due to its inverse relation) } , and nuclear morphometry at the ITF are better prognosticators.
This combination proved to be an accurate predictive factor in eliciting the varied molecular characteristics of tumor heterogeneity.
American Psychological Association (APA)
Vedam, V. K. Vaishnavi& Boaz, Karen& Natarajan, Srikant. 2014. Prognostic Efficacy of Nuclear Morphometry at Invasive Front of Oral Squamous Cell Carcinoma: An Image Analysis Microscopic Study. Analytical Cellular Pathology،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1015282
Modern Language Association (MLA)
Vedam, V. K. Vaishnavi…[et al.]. Prognostic Efficacy of Nuclear Morphometry at Invasive Front of Oral Squamous Cell Carcinoma: An Image Analysis Microscopic Study. Analytical Cellular Pathology No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1015282
American Medical Association (AMA)
Vedam, V. K. Vaishnavi& Boaz, Karen& Natarajan, Srikant. Prognostic Efficacy of Nuclear Morphometry at Invasive Front of Oral Squamous Cell Carcinoma: An Image Analysis Microscopic Study. Analytical Cellular Pathology. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1015282
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1015282