Registration between Pathological Image and MR Image for Comparing Different Modality Images of Brain Tumor

Abstract EN

Magnetic resonance imaging (MRI) is a preferred modality for brain tumor detection and preoperative localization.

However, invasive regions of tumor are often unclear in MR image and thus it is difficult to identify tumor from MR image.

Therefore, for revealing the relationship between cells and genetic information of the tumor of MR image, it is required to compare pathological images with MR images on the same regions.

In this study, we deal with glioblastoma among brain tumors.

However, it would be difficult to compare them directly because pathological images are deformed through tissue specimen making.

Thus, registration from MR image to pathological image is performed through the macroimage of cross section which is taken before cutting the brain into blocks.

Pathological image to be compared with MR image is combined from multiple histology images and deformed by referring the macroimage.

The detail of this technique is described in another paper submitted to this conference IADP2014.

In this paper, we assume to have obtained such a pathological image.

It is necessary to search appropriate curved plane from MR image because macroimage to be referred in merging pathological images has a possibility to be extracted as a curved plane from brain.