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Spectrally Encoded Confocal Microscopy for Guiding Lumpectomy
Joint Authors
Brachtel, Elena F.
Smith, Barbara L.
Tearney, Guillermo J.
Kang, Dongkyun
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-2, 2 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-11-19
Country of Publication
Egypt
No. of Pages
2
Main Subjects
Abstract EN
Complete removal of breast cancer during a single breast-conserving lumpectomy procedure is often challenging due to the lack of adequate intraoperative tools to accurately determine the margin status.
About one-third of lumpectomy patients are found to have positive margins upon final histologic analysis, which usually is reported within a week after surgery.
These patients are then required to undergo additional surgeries, which increases the patient morbidity, cosmetic challenges, and healthcare cost.
Spectrally encoded confocal microscopy (SECM) is a high-speed confocal microscopy technique [1] that can visualize cellular and subcellular features of an unstained fresh tissue.
SECM is 10–100 times faster than conventional confocal microscopes and has been demonstrated to image an entire endoscopic mucosal resection (EMR) esophageal tissue (10 mm by 10 mm) within 15 seconds [2].
The high imaging speed of SECM may make it possible to rapidly image the margins of entire lumpectomy specimens to comprehensively determine margin status without sampling error.
Real-time feedback regarding the margin status could enable the surgeon to achieve more thorough tumor removal in a single surgery and will significantly reduce the need for additional surgeries.
The aim of this preliminary study was to test SECM for visualizing breast cancers with various morphologic features.
American Psychological Association (APA)
Brachtel, Elena F.& Smith, Barbara L.& Tearney, Guillermo J.& Kang, Dongkyun. 2014. Spectrally Encoded Confocal Microscopy for Guiding Lumpectomy. Analytical Cellular Pathology،Vol. 2014, no. 2014, pp.1-2.
https://search.emarefa.net/detail/BIM-1015303
Modern Language Association (MLA)
Brachtel, Elena F.…[et al.]. Spectrally Encoded Confocal Microscopy for Guiding Lumpectomy. Analytical Cellular Pathology No. 2014 (2014), pp.1-2.
https://search.emarefa.net/detail/BIM-1015303
American Medical Association (AMA)
Brachtel, Elena F.& Smith, Barbara L.& Tearney, Guillermo J.& Kang, Dongkyun. Spectrally Encoded Confocal Microscopy for Guiding Lumpectomy. Analytical Cellular Pathology. 2014. Vol. 2014, no. 2014, pp.1-2.
https://search.emarefa.net/detail/BIM-1015303
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1015303