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Prevalence and Specificity of RBC Alloantibodies in Indian Patients Attending a Tertiary Care Hospital
Joint Authors
Zaman, Shamsuz
Chaurasia, Rahul
Chatterjee, Kabita
Thapliyal, Rakesh Mohan
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-10-16
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Red blood cell (RBC) alloimmunization results from genetic disparity of RBC antigens between donor and recipients.
Data about alloimmunization rate in general patient population is scarce especially from resource limited countries.
We undertook this study to determine prevalence and specificity of RBC alloantibodies in patients admitted in various clinical specialties at a tertiary care hospital in North India.
Methods.
Antibody screening was carried out in 11,235 patients on automated QWALYS 3 platform (Diagast, Loos, France).
Antibody identification was carried out with an 11-cell identification panel (ID-Diapanel, Diamed GmbH, Switzerland).
Results.
The overall incidence of RBC alloimmunization in transfused patients was 1.4% (157/11235), with anti-E being the most common specificity (36.3%), followed by anti-D (16%), anti-c (6.4%), anti-c + E (6.4%), anti-C + D (5.1%), and anti-K (4.5%).
The highest incidence of alloimmunization was observed in hematology/oncology patients (1.9%), whereas in other specialties the range was 0.7–1%.
Conclusion.
As alloimmunization complicates the transfusion outcomes, authors recommend pretransfusion antibody screening and issue of Rh and Kell matched blood to patients who warrant high transfusion requirements in future.
American Psychological Association (APA)
Zaman, Shamsuz& Chaurasia, Rahul& Chatterjee, Kabita& Thapliyal, Rakesh Mohan. 2014. Prevalence and Specificity of RBC Alloantibodies in Indian Patients Attending a Tertiary Care Hospital. Advances in Hematology،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1015350
Modern Language Association (MLA)
Zaman, Shamsuz…[et al.]. Prevalence and Specificity of RBC Alloantibodies in Indian Patients Attending a Tertiary Care Hospital. Advances in Hematology No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-1015350
American Medical Association (AMA)
Zaman, Shamsuz& Chaurasia, Rahul& Chatterjee, Kabita& Thapliyal, Rakesh Mohan. Prevalence and Specificity of RBC Alloantibodies in Indian Patients Attending a Tertiary Care Hospital. Advances in Hematology. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1015350
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1015350