Evaluation of Prothrombin Time and Activated Partial Thromboplastin Time in Hypertensive Patients Attending a Tertiary Hospital in Calabar, Nigeria
Joint Authors
Nnenna Adaeze, Nnamani
Uchenna Emeribe, Anthony
Abdullahi Nasiru, Idris
Babayo, Adamu
Uko, Emmanuel K.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-11-16
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Several biomedical findings have established the effects of hypertension on haemostasis and roles of blood coagulation products in the clinical course of hypertension.
Methods.
This cross-sectional study aimed at determining effects of hypertension on prothrombin time (PT) and activated partial thromboplastin time (APTT) in hypertensive patients in comparison with normotensive subjects attending a tertiary hospital in Calabar.
Forty-two (42) hypertensive patients and thirty-nine (39) normotensive control subjects were investigated for PT and APTT using Quick one-stage methods.
Results.
Systolic blood pressure (SBP) and diastolic blood pressure (DBP) correlated positively with APTT (r=0.3072, r=0.4988; P<0.05) in hypertensive patients.
DBP, SBP, PT, and APTT were significantly higher in hypertensive patients when compared to normotensive subjects (P<0.05).
DBP correlated negatively with duration of illness (r=-0.3097; P<0.05) in hypertensive patients and positively with age of normotensive subjects (r=0.3523; P<0.05).
Conclusion.
The results obtained indicated that measurements of PT and APTT may serve as indices for evaluating hemostatic abnormalities in hypertensive patients and guide for antihypertensive therapy.
However, to have better understanding of hemostatic activities in hypertension, it is recommended to conduct D-dimer, platelet factors, and protein assays.
American Psychological Association (APA)
Nnenna Adaeze, Nnamani& Uchenna Emeribe, Anthony& Abdullahi Nasiru, Idris& Babayo, Adamu& Uko, Emmanuel K.. 2014. Evaluation of Prothrombin Time and Activated Partial Thromboplastin Time in Hypertensive Patients Attending a Tertiary Hospital in Calabar, Nigeria. Advances in Hematology،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1015355
Modern Language Association (MLA)
Nnenna Adaeze, Nnamani…[et al.]. Evaluation of Prothrombin Time and Activated Partial Thromboplastin Time in Hypertensive Patients Attending a Tertiary Hospital in Calabar, Nigeria. Advances in Hematology No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1015355
American Medical Association (AMA)
Nnenna Adaeze, Nnamani& Uchenna Emeribe, Anthony& Abdullahi Nasiru, Idris& Babayo, Adamu& Uko, Emmanuel K.. Evaluation of Prothrombin Time and Activated Partial Thromboplastin Time in Hypertensive Patients Attending a Tertiary Hospital in Calabar, Nigeria. Advances in Hematology. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1015355
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1015355