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Effects of Atorvastatin on Oxidative Stress Biomarkers and Mitochondrial Morphofunctionality in Hyperfibrinogenemia-Induced Atherogenesis
Joint Authors
Scribano, María de la Paz
Baez, María del Carmen
Florencia, Becerra
Tarán, Mariana Denise
Franco, Signorini
Balceda, Ariel G.
Moya, Mónica
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-10-22
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Relationship between hyperfibrinogenemia (HF), oxidative stress, and atherogenesis was established.
Effect of atorvastatin (Ator) was assessed.
Wistar male (6 months) rats were studied: Ctr, control, without HF induction; Ctr-Ator, without HF treated with atorvastatin; AI, atherogenesis induced, and AI-Ator, atherogenesis induced and treated with atorvastatin.
Atherogenesis was induced by daily adrenaline injection (0.1 mL/day/rat) for 90 days; treatment started 15 days after induction.
Fibrinogen (mg/dL) and nitric oxide (NO) were measured in plasma (mM) and superoxide dismutase (SOD) (U/mL) in red cell lysate by spectrophotometry.
Slices of aorta were analyzed by electron microscopy (EM).
ANOVA and chi-square test were used; P<0.05 was established.
There were no significant differences between Ctr and Ctr-Atorv in fibrinogen, NO, and SOD values.
Comparing Ctr with AI an increase of fibrinogen is observed (P<0.001), but it decreased after administration of atorvastatin in AI-Ator (P<0.001).
NO diminished in AI relative to Ctr and increased in AI-Ator (P<0.001).
SOD showed an increase in AI and AI-Ator compared to Ctr (P<0.001).
EM revealed expansion of intermembrane space and disorganization of crests in AI.
In AI-Ator mitochondrial areas and diameters were similar to control.
Atorvastatin normalizes HF, stabilizes NO, increases SOD, and produces a partial regression of mitochondrial lesions.
American Psychological Association (APA)
Scribano, María de la Paz& Baez, María del Carmen& Florencia, Becerra& Tarán, Mariana Denise& Franco, Signorini& Balceda, Ariel G.…[et al.]. 2014. Effects of Atorvastatin on Oxidative Stress Biomarkers and Mitochondrial Morphofunctionality in Hyperfibrinogenemia-Induced Atherogenesis. Advances in Medicine،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1015505
Modern Language Association (MLA)
Scribano, María de la Paz…[et al.]. Effects of Atorvastatin on Oxidative Stress Biomarkers and Mitochondrial Morphofunctionality in Hyperfibrinogenemia-Induced Atherogenesis. Advances in Medicine No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1015505
American Medical Association (AMA)
Scribano, María de la Paz& Baez, María del Carmen& Florencia, Becerra& Tarán, Mariana Denise& Franco, Signorini& Balceda, Ariel G.…[et al.]. Effects of Atorvastatin on Oxidative Stress Biomarkers and Mitochondrial Morphofunctionality in Hyperfibrinogenemia-Induced Atherogenesis. Advances in Medicine. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1015505
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1015505