Synthesis and Characterization of Star-Shaped Block Copolymer sPCL-b-PEG-GA
Joint Authors
Zhang, Yi
Zhao, Qian
Shao, Hewei
Zhang, Shiyu
Han, Xiaoyan
Source
Advances in Materials Science and Engineering
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-26
Country of Publication
Egypt
No. of Pages
6
Abstract EN
Compared to linear polymers with the same molecular weight, star-shaped polymers have the superiority of drug loading and delivery.
The glycyrrhetinic acid (GA) from licorice is remarkably characteristic of liver distribution and liver cells targetability.
In this paper, four-armed star-shaped polycaprolactone was synthesized and amino polyethylene glycol was modified by glycyrrhetinic acid (NH2-PEG-GA).
Then the condensation reaction between the two above polymers finally produced four-armed star-shaped poly(ethylene glycol)-b-poly(ε-caprolactone) block copolymer (sPCL-b-PEG-GA).
The structures of the intermediates and product were characterized by 1H NMR.
The results indicated that the structure and molecular weight of sPCL-b-PEG-GA can be controlled by the varied ratios of pentaerythritol (PTOL) to ε-caprolactone (ε-CL) in the presence of stannous octoate (Sn(Oct)2), and the amphiphilic copolymer sPCL-b-PEG-GA consists of PTOL as core, PCL as inner hydrophobic segments, PEG as external hydrophilic segments, and terminal glycyrrhetic acid as targeting ligand.
The work explored a new synthesis route of star poly(ethylene glycol)-b-poly(ε-caprolactone) copolymer with liver targetability.
The star-shaped polymer is expected to be an efficient drug carrier.
American Psychological Association (APA)
Zhang, Yi& Zhao, Qian& Shao, Hewei& Zhang, Shiyu& Han, Xiaoyan. 2014. Synthesis and Characterization of Star-Shaped Block Copolymer sPCL-b-PEG-GA. Advances in Materials Science and Engineering،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1015576
Modern Language Association (MLA)
Zhang, Yi…[et al.]. Synthesis and Characterization of Star-Shaped Block Copolymer sPCL-b-PEG-GA. Advances in Materials Science and Engineering No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1015576
American Medical Association (AMA)
Zhang, Yi& Zhao, Qian& Shao, Hewei& Zhang, Shiyu& Han, Xiaoyan. Synthesis and Characterization of Star-Shaped Block Copolymer sPCL-b-PEG-GA. Advances in Materials Science and Engineering. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1015576
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1015576