Synthesis, Characterization, DNA Interaction, and Antitumor Activities of La (III) Complex with Schiff Base Ligand Derived from Kaempferol and Diethylenetriamine
Joint Authors
Wang, Qin
Huang, Yu
Zhang, Jin-Sheng
Yang, Xin-Bin
Source
Bioinorganic Chemistry and Applications
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-10-12
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
A novel La (III) complex, [LaL(H2O)3]NO3·3H2O, with Schiff base ligand L derived from kaempferol and diethylenetriamine, has been synthesized and characterized by elemental analysis, IR, UV-visible, 1H NMR, thermogravimetric analysis, and molar conductance measurements.
The fluorescence spectra, circular dichroism spectra, and viscosity measurements and gel electrophoresis experiments indicated that the ligand L and La (III) complex could bind to CT-DNA presumably via intercalative mode and the La (III) complex showed a stronger ability to bind and cleave DNA than the ligand L alone.
The binding constants (Kb) were evaluated from fluorescence data and the values ranged from 0.454 to 0.659 × 105 L mol−1 and 1.71 to 17.3 × 105 L mol−1 for the ligand L and La (III) complex, respectively, in the temperature range of 298–310 K.
It was also found that the fluorescence quenching mechanism of EB-DNA by ligand L and La (III) complex was a static quenching process.
In comparison to free ligand L, La (III) complex exhibited enhanced cytotoxic activities against tested tumor cell lines HL-60 and HepG-2, which may correlate with the enhanced DNA binding and cleaving abilities of the La (III) complex.
American Psychological Association (APA)
Wang, Qin& Huang, Yu& Zhang, Jin-Sheng& Yang, Xin-Bin. 2014. Synthesis, Characterization, DNA Interaction, and Antitumor Activities of La (III) Complex with Schiff Base Ligand Derived from Kaempferol and Diethylenetriamine. Bioinorganic Chemistry and Applications،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1016067
Modern Language Association (MLA)
Wang, Qin…[et al.]. Synthesis, Characterization, DNA Interaction, and Antitumor Activities of La (III) Complex with Schiff Base Ligand Derived from Kaempferol and Diethylenetriamine. Bioinorganic Chemistry and Applications No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1016067
American Medical Association (AMA)
Wang, Qin& Huang, Yu& Zhang, Jin-Sheng& Yang, Xin-Bin. Synthesis, Characterization, DNA Interaction, and Antitumor Activities of La (III) Complex with Schiff Base Ligand Derived from Kaempferol and Diethylenetriamine. Bioinorganic Chemistry and Applications. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1016067
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1016067