Antioxidant Enzyme Inhibitor Role of Phosphine Metal Complexes in Lung and Leukemia Cell Lines
Joint Authors
Saygıdeğer Demir, Burcu
Keleş, Tuğba
Serindağ, Osman
Source
Bioinorganic Chemistry and Applications
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-12-28
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Phosphine metal complexes have been recently evaluated in the field of cancer therapy.
In this research, the cytotoxic effects of some metal phosphines { [PdCl2((CH2OH)2PCH2)2NCH3] (C1), [RuCl2(((CH2OH)2PCH2)2NCH3)2] (C2), [PtCl2((Ph2PCH2)2NCH3)(timin)2] (C3) } on K562 (human myelogenous leukemia cell line) and A549 (adenocarcinomic human alveolar basal epithelial cells) cells were investigated using the MTT test.
C1 and C2 are water-soluble metal complexes, which may have some advantages in in vitro and in vivo studies.
The effects of the above-mentioned metal complexes on thioredoxin reductase (TrxR) (EC: 1.8.1.9), glutathione peroxidase (GPx) (EC: 1.11.1.9), and catalase (Cat) (EC: 1.11.1.6) enzymes were also tested.
The results of this research showed that all three metal complexes indicated dose-dependent cytotoxicity on A549 and K562 cell lines and that the complexes inhibited different percentages of the TrxR, GPx, and Cat enzymes of these tumor cells.
American Psychological Association (APA)
Saygıdeğer Demir, Burcu& Keleş, Tuğba& Serindağ, Osman. 2014. Antioxidant Enzyme Inhibitor Role of Phosphine Metal Complexes in Lung and Leukemia Cell Lines. Bioinorganic Chemistry and Applications،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1016076
Modern Language Association (MLA)
Saygıdeğer Demir, Burcu…[et al.]. Antioxidant Enzyme Inhibitor Role of Phosphine Metal Complexes in Lung and Leukemia Cell Lines. Bioinorganic Chemistry and Applications No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1016076
American Medical Association (AMA)
Saygıdeğer Demir, Burcu& Keleş, Tuğba& Serindağ, Osman. Antioxidant Enzyme Inhibitor Role of Phosphine Metal Complexes in Lung and Leukemia Cell Lines. Bioinorganic Chemistry and Applications. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1016076
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1016076