Synthesis, Characterization, and Biological Activity of N′-[(Z)-(3-Methyl-5-oxo-1-phenyl-1,5-dihydro-4H-pyrazol-4-ylidene)(phenyl)methyl]benzohydrazide and Its Co(II), Ni(II), and Cu(II) Complexes
Joint Authors
Asegbeloyin, Jonnie N.
Ujam, Oguejiofo T.
Okafor, Emmanuel C.
Babahan, Ilknur
Coban, Esin Poyrazoglu
Özmen, Ali
Biyik, Halil
Source
Bioinorganic Chemistry and Applications
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-15
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Reaction of 1-phenyl-3-methyl-4-benzoyl-pyrazol-5-one and benzoyl hydrazide in refluxing ethanol gave N′-[(Z)-(3-methyl-5-oxo-1-phenyl-1,5-dihydro-4H-pyrazol-4-ylidene)(phenyl)methyl]benzohydrazide (HL1), which was characterized by NMR spectroscopy and single-crystal X-ray structure study.
X-ray diffraction analyses of the crystals revealed a nonplanar molecule, existing in the keto-amine form, with intermolecular hydrogen bonding forming a seven-membered ring system.
The reaction of HL1 with Co(II), Ni(II), and Cu(II) halides gave the corresponding complexes, which were characterized by elemental analysis, molar conductance, magnetic measurements, and infrared and electronic spectral studies.
The compounds were screened for their in vitro cytotoxic activity against HL-60 human promyelocytic leukemia cells and antimicrobial activity against some bacteria and yeasts.
Results showed that the compounds are potent against HL-60 cells with the IC50 value ≤5 μM, while some of the compounds were active against few studied Gram-positive bacteria.
American Psychological Association (APA)
Asegbeloyin, Jonnie N.& Ujam, Oguejiofo T.& Okafor, Emmanuel C.& Babahan, Ilknur& Coban, Esin Poyrazoglu& Özmen, Ali…[et al.]. 2014. Synthesis, Characterization, and Biological Activity of N′-[(Z)-(3-Methyl-5-oxo-1-phenyl-1,5-dihydro-4H-pyrazol-4-ylidene)(phenyl)methyl]benzohydrazide and Its Co(II), Ni(II), and Cu(II) Complexes. Bioinorganic Chemistry and Applications،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1016077
Modern Language Association (MLA)
Asegbeloyin, Jonnie N.…[et al.]. Synthesis, Characterization, and Biological Activity of N′-[(Z)-(3-Methyl-5-oxo-1-phenyl-1,5-dihydro-4H-pyrazol-4-ylidene)(phenyl)methyl]benzohydrazide and Its Co(II), Ni(II), and Cu(II) Complexes. Bioinorganic Chemistry and Applications No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1016077
American Medical Association (AMA)
Asegbeloyin, Jonnie N.& Ujam, Oguejiofo T.& Okafor, Emmanuel C.& Babahan, Ilknur& Coban, Esin Poyrazoglu& Özmen, Ali…[et al.]. Synthesis, Characterization, and Biological Activity of N′-[(Z)-(3-Methyl-5-oxo-1-phenyl-1,5-dihydro-4H-pyrazol-4-ylidene)(phenyl)methyl]benzohydrazide and Its Co(II), Ni(II), and Cu(II) Complexes. Bioinorganic Chemistry and Applications. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1016077
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1016077