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MicroRNA as New Tools for Prostate Cancer Risk Assessment and Therapeutic Intervention: Results from Clinical Data Set and Patients’ Samples
Joint Authors
Cannistraci, Alessio
Di Pace, Anna Laura
De Maria, Ruggero
Bonci, Désirée
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-16
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Prostate cancer (PCa) is one of the leading causes of cancer-related death in men.
Despite considerable advances in prostate cancer early detection and clinical management, validation of new biomarkers able to predict the natural history of tumor progression is still necessary in order to reduce overtreatment and to guide therapeutic decisions.
MicroRNAs are endogenous noncoding RNAs which offer a fast fine-tuning and energy-saving mechanism for posttranscriptional control of protein expression.
Growing evidence indicate that these RNAs are able to regulate basic cell functions and their aberrant expression has been significantly correlated with cancer development.
Therefore, detection of microRNAs in tumor tissues and body fluids represents a new tool for early diagnosis and patient prognosis prediction.
In this review, we summarize current knowledge about microRNA deregulation in prostate cancer mainly focusing on the different clinical aspects of the disease.
We also highlight the potential roles of microRNAs in PCa management, while also discussing several current challenges and needed future research.
American Psychological Association (APA)
Cannistraci, Alessio& Di Pace, Anna Laura& De Maria, Ruggero& Bonci, Désirée. 2014. MicroRNA as New Tools for Prostate Cancer Risk Assessment and Therapeutic Intervention: Results from Clinical Data Set and Patients’ Samples. BioMed Research International،Vol. 2014, no. 2014, pp.1-17.
https://search.emarefa.net/detail/BIM-1016104
Modern Language Association (MLA)
Cannistraci, Alessio…[et al.]. MicroRNA as New Tools for Prostate Cancer Risk Assessment and Therapeutic Intervention: Results from Clinical Data Set and Patients’ Samples. BioMed Research International No. 2014 (2014), pp.1-17.
https://search.emarefa.net/detail/BIM-1016104
American Medical Association (AMA)
Cannistraci, Alessio& Di Pace, Anna Laura& De Maria, Ruggero& Bonci, Désirée. MicroRNA as New Tools for Prostate Cancer Risk Assessment and Therapeutic Intervention: Results from Clinical Data Set and Patients’ Samples. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-17.
https://search.emarefa.net/detail/BIM-1016104
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1016104