Quinolone-Containing Therapies in the Eradication of Helicobacter pylori
Joint Authors
Chuah, Seng-Kee
Hu, Tsung-Hui
Lee, Chen-Hsiang
Liang, Chih-Ming
Tai, Wei-Chen
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-28
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Fluoroquinolones, especially levofloxacin, are used in the eradication of Helicobacter pylori worldwide.
Many consensus guidelines recommend that the second-line rescue therapy for H.
pylori eradication consists of a proton pump inhibitor, a quinolone, and amoxicillin as an option.
Unfortunately, quinolone is well associated with a risk of developing bacterial resistance.
In this paper, we review quinolone-containing H.
pylori eradication regimens and the challenges that influence the efficacy of eradication.
It is generally suggested that the use of levofloxacin should be confined to “rescue” therapy only, in order to avoid a further rapid increase in the resistance of H.
pylori to quinolone.
The impact of quinolone-containing H.
pylori eradication regimens on public health issues such as tuberculosis treatment must always be taken into account.
Exposure to quinolone is relevant to delays in diagnosing tuberculosis and the development of drug resistance.
Extending the duration of treatment to 14 days improves eradication rates by >90%.
Tailored therapy to detect fluoroquinolone-resistant strains can be done by culture-based and molecular methods to provide better eradication rates.
Molecular methods are achieved by using a real-time polymerase chain reaction to detect the presence of a gyrA mutation, which is predictive of treatment failure with quinolones-containing triple therapy.
American Psychological Association (APA)
Chuah, Seng-Kee& Tai, Wei-Chen& Lee, Chen-Hsiang& Liang, Chih-Ming& Hu, Tsung-Hui. 2014. Quinolone-Containing Therapies in the Eradication of Helicobacter pylori. BioMed Research International،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1016106
Modern Language Association (MLA)
Chuah, Seng-Kee…[et al.]. Quinolone-Containing Therapies in the Eradication of Helicobacter pylori. BioMed Research International No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-1016106
American Medical Association (AMA)
Chuah, Seng-Kee& Tai, Wei-Chen& Lee, Chen-Hsiang& Liang, Chih-Ming& Hu, Tsung-Hui. Quinolone-Containing Therapies in the Eradication of Helicobacter pylori. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1016106
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1016106