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Sulfa Drugs as Inhibitors of Carbonic Anhydrase: New Targets for the Old Drugs
Joint Authors
Iqbal, Jamshed
al-Rashida, Mariya
Hussain, Sajad
Hamayoun, Mehwish
Altaf, Aisha
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-08
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Sulfa drugs are well-known antibacterial agents containing N-substituted sulfonamide group on para position of aniline ring (NH2RSO2NHR′).
In this study 2,4-dichloro-1,3,5-triazine derivatives of sulfa drugs, sulfamerazine (1b), sulfaquinoxaline (2b), sulfadiazine (3b), sulfadimidine (4b), and sulfachloropyrazine (5b) (1a–5a) were synthesized and characterized.
Their carbonic anhydrase inhibition activity was evaluated against bovine cytosolic carbonic anhydrase isozyme II (bCA II).
For the sake of comparison the CA inhibition activity of the parent sulfa drugs (1b–5b) was also evaluated.
A significant increase in CA inhibition activity of sulfa drugs was observed upon substitution with 2,4-dichloro-1,3,5-triazine moiety.
Molecular docking studies were carried out to highlight binding site interactions.
ADME properties were calculated to evaluate drug likeness of the compounds.
American Psychological Association (APA)
al-Rashida, Mariya& Hussain, Sajad& Hamayoun, Mehwish& Altaf, Aisha& Iqbal, Jamshed. 2014. Sulfa Drugs as Inhibitors of Carbonic Anhydrase: New Targets for the Old Drugs. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1016111
Modern Language Association (MLA)
al-Rashida, Mariya…[et al.]. Sulfa Drugs as Inhibitors of Carbonic Anhydrase: New Targets for the Old Drugs. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1016111
American Medical Association (AMA)
al-Rashida, Mariya& Hussain, Sajad& Hamayoun, Mehwish& Altaf, Aisha& Iqbal, Jamshed. Sulfa Drugs as Inhibitors of Carbonic Anhydrase: New Targets for the Old Drugs. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1016111
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1016111