Derailed Intraneuronal Signalling Drives Pathogenesis in Sporadic and Familial Alzheimer’s Disease
Joint Authors
Van Dooren, Tom
Princen, Katrien
De Witte, Koen
Griffioen, Gerard
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-26
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Although a wide variety of genetic and nongenetic Alzheimer’s disease (AD) risk factors have been identified, their role in onset and/or progression of neuronal degeneration remains elusive.
Systematic analysis of AD risk factors revealed that perturbations of intraneuronal signalling pathways comprise a common mechanistic denominator in both familial and sporadic AD and that such alterations lead to increases in Aβ oligomers (Aβo) formation and phosphorylation of TAU.
Conversely, Aβo and TAU impact intracellular signalling directly.
This feature entails binding of Aβo to membrane receptors, whereas TAU functionally interacts with downstream transducers.
Accordingly, we postulate a positive feedback mechanism in which AD risk factors or genes trigger perturbations of intraneuronal signalling leading to enhanced Aβo formation and TAU phosphorylation which in turn further derange signalling.
Ultimately intraneuronal signalling becomes deregulated to the extent that neuronal function and survival cannot be sustained, whereas the resulting elevated levels of amyloidogenic Aβo and phosphorylated TAU species self-polymerizes into the AD plaques and tangles, respectively.
American Psychological Association (APA)
Van Dooren, Tom& Princen, Katrien& De Witte, Koen& Griffioen, Gerard. 2014. Derailed Intraneuronal Signalling Drives Pathogenesis in Sporadic and Familial Alzheimer’s Disease. BioMed Research International،Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-1016113
Modern Language Association (MLA)
Van Dooren, Tom…[et al.]. Derailed Intraneuronal Signalling Drives Pathogenesis in Sporadic and Familial Alzheimer’s Disease. BioMed Research International No. 2014 (2014), pp.1-14.
https://search.emarefa.net/detail/BIM-1016113
American Medical Association (AMA)
Van Dooren, Tom& Princen, Katrien& De Witte, Koen& Griffioen, Gerard. Derailed Intraneuronal Signalling Drives Pathogenesis in Sporadic and Familial Alzheimer’s Disease. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-1016113
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1016113