![](/images/graphics-bg.png)
Age Dependent Differences in Collagen Alignment of Glutaraldehyde Fixed Bovine Pericardium
Joint Authors
Sizeland, Katie H.
Wells, Hannah C.
Higgins, John
Cunanan, Crystal M.
Kirby, Nigel
Hawley, Adrian
Mudie, Stephen T.
Haverkamp, Richard G.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-14
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Bovine pericardium is used for heart valve leaflet replacement where the strength and thinness are critical properties.
Pericardium from neonatal animals (4–7 days old) is advantageously thinner and is considered as an alternative to that from adult animals.
Here, the structures of adult and neonatal bovine pericardium tissues fixed with glutaraldehyde are characterized by synchrotron-based small angle X-ray scattering (SAXS) and compared with the mechanical properties of these materials.
Significant differences are observed between adult and neonatal tissue.
The glutaraldehyde fixed neonatal tissue has a higher modulus of elasticity (83.7 MPa) than adult pericardium (33.5 MPa) and a higher normalised ultimate tensile strength (32.9 MPa) than adult pericardium (19.1 MPa).
Measured edge on to the tissue, the collagen in neonatal pericardium is significantly more aligned (orientation index (OI) 0.78) than that in adult pericardium (OI 0.62).
There is no difference in the fibril diameter between neonatal and adult pericardium.
It is shown that high alignment in the plane of the tissue provides the mechanism for the increased strength of the neonatal material.
The superior strength of neonatal compared with adult tissue supports the use of neonatal bovine pericardium in heterografts.
American Psychological Association (APA)
Sizeland, Katie H.& Wells, Hannah C.& Higgins, John& Cunanan, Crystal M.& Kirby, Nigel& Hawley, Adrian…[et al.]. 2014. Age Dependent Differences in Collagen Alignment of Glutaraldehyde Fixed Bovine Pericardium. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1016131
Modern Language Association (MLA)
Sizeland, Katie H.…[et al.]. Age Dependent Differences in Collagen Alignment of Glutaraldehyde Fixed Bovine Pericardium. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1016131
American Medical Association (AMA)
Sizeland, Katie H.& Wells, Hannah C.& Higgins, John& Cunanan, Crystal M.& Kirby, Nigel& Hawley, Adrian…[et al.]. Age Dependent Differences in Collagen Alignment of Glutaraldehyde Fixed Bovine Pericardium. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1016131
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1016131