MicroRNA Dysregulation in Liver and Pancreas of CMP-Neu5Ac Hydroxylase Null Mice Disrupts InsulinPI3K-AKT Signaling
Joint Authors
Kim, Jin-Hoi
Kwon, Deug-Nam
Chang, Byung-Soo
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-27
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
CMP-Neu5Ac hydroxylase (Cmah)-null mice fed with a high-fat diet develop fasting hyperglycemia, glucose intolerance, and pancreatic β-cell dysfunction and ultimately develop characteristics of type 2 diabetes.
The precise metabolic role of the Cmah gene remains poorly understood.
This study was designed to investigate the molecular mechanisms through which microRNAs (miRNAs) regulate type 2 diabetes.
Expression profiles of miRNAs in Cmah-null mouse livers were compared to those of control mouse livers.
Liver miFinder miRNA PCR arrays (n=6) showed that eight miRNA genes were differentially expressed between the two groups.
Compared with controls, seven miRNAs were upregulated and one miRNA was downregulated in Cmah-null mice.
Specifically, miR-155-5p, miR-425-5p, miR-15a-5p, miR-503-5p, miR-16-5p, miR-29a-3p, and miR-29b-3p were significantly upregulated in the liver and pancreas of Cmah-null mice.
These target miRNAs are closely associated with dysregulation of insulin/PI3K-AKT signaling, suggesting that the Cmah-null mice could be a useful model for studying diabetes.
American Psychological Association (APA)
Kwon, Deug-Nam& Chang, Byung-Soo& Kim, Jin-Hoi. 2014. MicroRNA Dysregulation in Liver and Pancreas of CMP-Neu5Ac Hydroxylase Null Mice Disrupts InsulinPI3K-AKT Signaling. BioMed Research International،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1016163
Modern Language Association (MLA)
Kwon, Deug-Nam…[et al.]. MicroRNA Dysregulation in Liver and Pancreas of CMP-Neu5Ac Hydroxylase Null Mice Disrupts InsulinPI3K-AKT Signaling. BioMed Research International No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-1016163
American Medical Association (AMA)
Kwon, Deug-Nam& Chang, Byung-Soo& Kim, Jin-Hoi. MicroRNA Dysregulation in Liver and Pancreas of CMP-Neu5Ac Hydroxylase Null Mice Disrupts InsulinPI3K-AKT Signaling. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1016163
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1016163