Common Polymorphism in the LRP5 Gene May Increase the Risk of Bone Fracture and Osteoporosis
Joint Authors
Xu, Guang-Yue
Qiu, Yong
Mao, Hai-Jun
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-12-14
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The low-density lipoprotein receptor-related protein 5 gene (LRP5) was identified to be linked to the variation in bone mineral density and types of bone diseases.
The present study was aimed at examining the association of LRP5 rs3736228 C>T gene with bone fracture and osteoporosis by meta-analysis.
A systematic electronic search of literature was conducted to identify all published studies in English or Chinese on the association of the LRP5 gene with bone fracture and osteoporosis risks.
All analyses were calculated using the Version 12.0 STATA software.
Odds ratios (ORs) and their corresponding 95% confidence interval (95% CI) were calculated.
An updated meta-analysis was currently performed, including seven independent case-control studies.
Results identified that carriers of rs3736228 C>T variant in the LRP5 gene were associated with an increased risk of developing osteoporosis and fractures under 4 genetic models but not under the dominant model (OR = 1.19, 95% CI = 0.97~1.46, and P=0.103).
Ethnicity-subgroup analysis implied that LRP5 rs3736228 C>T mutation was more likely to develop osteoporosis and fractures among Asians and Caucasians in majority of subgroups.
These results suggest that there is a modest effect of the LRP5 rs3736228 C>T on the increased susceptibility of bone fracture and osteoporosis.
American Psychological Association (APA)
Xu, Guang-Yue& Qiu, Yong& Mao, Hai-Jun. 2014. Common Polymorphism in the LRP5 Gene May Increase the Risk of Bone Fracture and Osteoporosis. BioMed Research International،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1016204
Modern Language Association (MLA)
Xu, Guang-Yue…[et al.]. Common Polymorphism in the LRP5 Gene May Increase the Risk of Bone Fracture and Osteoporosis. BioMed Research International No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-1016204
American Medical Association (AMA)
Xu, Guang-Yue& Qiu, Yong& Mao, Hai-Jun. Common Polymorphism in the LRP5 Gene May Increase the Risk of Bone Fracture and Osteoporosis. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1016204
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1016204