Symbiotic Plant Peptides Eliminate Candida albicans Both In Vitro and in an Epithelial Infection Model and Inhibit the Proliferation of Immortalized Human Cells
Joint Authors
Ördögh, Lilla
Vörös, Andrea
Nagy, István
Kondorosi, Éva
Kereszt, Attila
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-28
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The increasing number of multidrug-resistant microbes now emerging necessitates the identification of novel antimicrobial agents.
Plants produce a great variety of antimicrobial peptides including hundreds of small, nodule-specific cysteine-rich NCR peptides that, in the legume Medicago truncatula, govern the differentiation of endosymbiotic nitrogen fixing bacteria and, in vitro, can display potent antibacterial activities.
In this study, the potential candidacidal activity of 19 NCR peptides was investigated.
Cationic NCR peptides having an isoelectric point above 9 were efficient in killing Candida albicans, one of the most common fungal pathogens of humans.
None of the tested NCR peptides were toxic for immortalized human epithelial cells at concentrations that effectively killed the fungus; however, at higher concentrations, some of them inhibited the division of the cells.
Furthermore, the cationic peptides successfully inhibited C.
albicans induced human epithelial cell death in an in vitro coculture model.
These results highlight the therapeutic potential of cationic NCR peptides in the treatment of candidiasis.
American Psychological Association (APA)
Ördögh, Lilla& Vörös, Andrea& Nagy, István& Kondorosi, Éva& Kereszt, Attila. 2014. Symbiotic Plant Peptides Eliminate Candida albicans Both In Vitro and in an Epithelial Infection Model and Inhibit the Proliferation of Immortalized Human Cells. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1016225
Modern Language Association (MLA)
Ördögh, Lilla…[et al.]. Symbiotic Plant Peptides Eliminate Candida albicans Both In Vitro and in an Epithelial Infection Model and Inhibit the Proliferation of Immortalized Human Cells. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1016225
American Medical Association (AMA)
Ördögh, Lilla& Vörös, Andrea& Nagy, István& Kondorosi, Éva& Kereszt, Attila. Symbiotic Plant Peptides Eliminate Candida albicans Both In Vitro and in an Epithelial Infection Model and Inhibit the Proliferation of Immortalized Human Cells. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1016225
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1016225