Association Analysis between g.18873C>T and g.27522G>A Genetic Polymorphisms of OPG and Bone Mineral Density in Chinese Postmenopausal Women

Joint Authors

Wang, Fei
Cao, Yi
Li, Fang
Shan, Jianlin
Wen, Tianlin

Source

BioMed Research International

Issue

Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2014-12-14

Country of Publication

Egypt

No. of Pages

5

Main Subjects

Medicine

Abstract EN

Several studies report that the OPG is an important candidate gene in the pathogenesis of osteoporosis.

This study aimed to detect the potential association of OPG gene polymorphisms with osteoporosis in postmenopausal women.

We recruited 928 subjects containing 463 with primary postmenopausal osteoporosis and 465 healthy volunteers as controls.

The BMD of neck hip, lumbar spine (L2–4), and total hip were assessed by dual-energy X-ray absorptiometry (DEXA).

Through the created restriction site-polymerase chain reaction (CRS-PCR), PCR-restriction fragment length polymorphism (PCR-RFLP), and DNA sequencing methods, the g.18873C>T and g.27522G>A have been investigated.

As for g.18873C>T, our data indicated that subjects with CC genotype have significantly higher BMD value than those of CT and TT genotypes (all P values < 0.05).

As for g.27522G>A, the BMD values of subjects with GG genotype were significantly higher than those of GA and AA genotypes (all P values < 0.05).

Our findings suggest that the OPG g.18873C>T and g.27522G>A genetic polymorphisms are associated with the decreased risk for osteoporosis in Chinese postmenopausal women.

American Psychological Association (APA)

Wang, Fei& Cao, Yi& Li, Fang& Shan, Jianlin& Wen, Tianlin. 2014. Association Analysis between g.18873C>T and g.27522G>A Genetic Polymorphisms of OPG and Bone Mineral Density in Chinese Postmenopausal Women. BioMed Research International،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1016226

Modern Language Association (MLA)

Wang, Fei…[et al.]. Association Analysis between g.18873C>T and g.27522G>A Genetic Polymorphisms of OPG and Bone Mineral Density in Chinese Postmenopausal Women. BioMed Research International No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-1016226

American Medical Association (AMA)

Wang, Fei& Cao, Yi& Li, Fang& Shan, Jianlin& Wen, Tianlin. Association Analysis between g.18873C>T and g.27522G>A Genetic Polymorphisms of OPG and Bone Mineral Density in Chinese Postmenopausal Women. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1016226

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1016226