Association Analysis between g.18873C>T and g.27522G>A Genetic Polymorphisms of OPG and Bone Mineral Density in Chinese Postmenopausal Women
Joint Authors
Wang, Fei
Cao, Yi
Li, Fang
Shan, Jianlin
Wen, Tianlin
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-12-14
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Several studies report that the OPG is an important candidate gene in the pathogenesis of osteoporosis.
This study aimed to detect the potential association of OPG gene polymorphisms with osteoporosis in postmenopausal women.
We recruited 928 subjects containing 463 with primary postmenopausal osteoporosis and 465 healthy volunteers as controls.
The BMD of neck hip, lumbar spine (L2–4), and total hip were assessed by dual-energy X-ray absorptiometry (DEXA).
Through the created restriction site-polymerase chain reaction (CRS-PCR), PCR-restriction fragment length polymorphism (PCR-RFLP), and DNA sequencing methods, the g.18873C>T and g.27522G>A have been investigated.
As for g.18873C>T, our data indicated that subjects with CC genotype have significantly higher BMD value than those of CT and TT genotypes (all P values < 0.05).
As for g.27522G>A, the BMD values of subjects with GG genotype were significantly higher than those of GA and AA genotypes (all P values < 0.05).
Our findings suggest that the OPG g.18873C>T and g.27522G>A genetic polymorphisms are associated with the decreased risk for osteoporosis in Chinese postmenopausal women.
American Psychological Association (APA)
Wang, Fei& Cao, Yi& Li, Fang& Shan, Jianlin& Wen, Tianlin. 2014. Association Analysis between g.18873C>T and g.27522G>A Genetic Polymorphisms of OPG and Bone Mineral Density in Chinese Postmenopausal Women. BioMed Research International،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1016226
Modern Language Association (MLA)
Wang, Fei…[et al.]. Association Analysis between g.18873C>T and g.27522G>A Genetic Polymorphisms of OPG and Bone Mineral Density in Chinese Postmenopausal Women. BioMed Research International No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-1016226
American Medical Association (AMA)
Wang, Fei& Cao, Yi& Li, Fang& Shan, Jianlin& Wen, Tianlin. Association Analysis between g.18873C>T and g.27522G>A Genetic Polymorphisms of OPG and Bone Mineral Density in Chinese Postmenopausal Women. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1016226
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1016226