Therapeutic Efficacy of pH-Dependent Release Formulation of Mesalazine on Active Ulcerative Colitis Resistant to Time-Dependent Release Formulation: Analysis of Fecal Calprotectin Concentration
Joint Authors
Kawashima, Kousaku
Ishihara, Shunji
Yuki, Takafumi
Onishi, Koji
Kushiyama, Yoshinori
Fujishiro, Hirofumi
Miyaoka, Youichi
Yuki, Mika
Komazawa, Yoshinori
Tanimura, Takashi
Sonoyama, Hiroki
Tada, Yasumasa
Kusunoki, Ryusaku
Oka, Akihiko
Fukuba, Nobuhiko
Oshima, Naoki
Moriyama, Ichiro
Kinoshita, Yoshikazu
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-11-18
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Purpose.
Few reports have compared the clinical efficacy of a pH-dependent release formulation of mesalazine (pH-5-ASA) with a time-dependent release formulation (time-5-ASA).
We examined whether pH-5-ASA is effective for active ulcerative colitis (UC) in patients resistant to time-5-ASA.
Methods.
We retrospectively and prospectively analyzed the efficacy of pH-5-ASA in mildly to moderately active UC patients in whom time-5-ASA did not successfully induce or maintain remission.
The clinical efficacy of pH-5-ASA was assessed by clinical activity index (CAI) before and after switching from time-5-ASA.
In addition, the efficacy of pH-5-ASA on mucosal healing (MH) was evaluated in a prospective manner by measuring fecal calprotectin concentration.
Results.
Thirty patients were analyzed in a retrospective manner.
CAI was significantly reduced at both 4 and 8 weeks after switching to pH-5-ASA.
In the prospective study ( n = 14 ), administration of pH-5-ASA also significantly reduced CAI scores at 4 and 8 weeks in these patients who were resistant to time-5-ASA.
In addition, fecal calprotectin concentration was significantly decreased along with improvement in CAI after switching to pH-5-ASA.
Conclusions.
Our results suggest that pH-5-ASA has clinical efficacy for mildly to moderately active patients with UC in whom time-5-ASA did not successfully induce or maintain remission.
American Psychological Association (APA)
Kawashima, Kousaku& Ishihara, Shunji& Yuki, Takafumi& Onishi, Koji& Kushiyama, Yoshinori& Fujishiro, Hirofumi…[et al.]. 2014. Therapeutic Efficacy of pH-Dependent Release Formulation of Mesalazine on Active Ulcerative Colitis Resistant to Time-Dependent Release Formulation: Analysis of Fecal Calprotectin Concentration. BioMed Research International،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1016237
Modern Language Association (MLA)
Kawashima, Kousaku…[et al.]. Therapeutic Efficacy of pH-Dependent Release Formulation of Mesalazine on Active Ulcerative Colitis Resistant to Time-Dependent Release Formulation: Analysis of Fecal Calprotectin Concentration. BioMed Research International No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1016237
American Medical Association (AMA)
Kawashima, Kousaku& Ishihara, Shunji& Yuki, Takafumi& Onishi, Koji& Kushiyama, Yoshinori& Fujishiro, Hirofumi…[et al.]. Therapeutic Efficacy of pH-Dependent Release Formulation of Mesalazine on Active Ulcerative Colitis Resistant to Time-Dependent Release Formulation: Analysis of Fecal Calprotectin Concentration. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1016237
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1016237