Management of Non-Vitamin K Antagonist Oral Anticoagulants in the Perioperative Setting
Joint Authors
Jean-Michel, Dogné
Maximilien, Gourdin
François, Mullier
Jonathan, Douxfils
Sarah, Lessire
Anne-Sophie, Dincq
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-03
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
The field of oral anticoagulation has evolved with the arrival of non-vitamin K antagonist oral anticoagulants (NOACs) including an anti-IIa agent (dabigatran etexilate) and anti-Xa agents (rivaroxaban and apixaban).
The main specificities of these drugs are predictable pharmacokinetics and pharmacodynamics but special attention should be paid in the elderly, in case of renal dysfunction and in case of emergency.
In addition, their perioperative management is challenging, especially with the absence of specific antidotes.
Effectively, periods of interruption before surgery or invasive procedures depend on half-life and keeping a permanent balance between bleeding and thromboembolic risks.
In addition, few data regarding the link between plasma concentrations and their effects are provided.
Routine laboratory tests are altered by NOACs and quantitative measurements are not widely performed.
This paper provides a review on the management of NOACs in the perioperative setting, including the estimation of the bleeding and thrombotic risk, the periods of interruption, the indication of heparin bridging, the usefulness of laboratory tests before surgery or invasive procedure, and the time of resuming.
Most data are based on expert’s opinions.
American Psychological Association (APA)
Anne-Sophie, Dincq& Sarah, Lessire& Jonathan, Douxfils& Jean-Michel, Dogné& Maximilien, Gourdin& François, Mullier. 2014. Management of Non-Vitamin K Antagonist Oral Anticoagulants in the Perioperative Setting. BioMed Research International،Vol. 2014, no. 2014, pp.1-16.
https://search.emarefa.net/detail/BIM-1016264
Modern Language Association (MLA)
Anne-Sophie, Dincq…[et al.]. Management of Non-Vitamin K Antagonist Oral Anticoagulants in the Perioperative Setting. BioMed Research International No. 2014 (2014), pp.1-16.
https://search.emarefa.net/detail/BIM-1016264
American Medical Association (AMA)
Anne-Sophie, Dincq& Sarah, Lessire& Jonathan, Douxfils& Jean-Michel, Dogné& Maximilien, Gourdin& François, Mullier. Management of Non-Vitamin K Antagonist Oral Anticoagulants in the Perioperative Setting. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-16.
https://search.emarefa.net/detail/BIM-1016264
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1016264