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CCR7 Regulates Cell Migration and Invasion through JAK2STAT3 in Metastatic Squamous Cell Carcinoma of the Head and Neck
Joint Authors
Liu, Fa-Yu
Safdar, Jawad
Li, Zhen-Ning
Fang, Qi-Gen
Zhang, Xu
Xu, Zhong-Fei
Sun, Chang-Fu
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-10-27
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Squamous cell carcinoma of the head and neck (SCCHN) frequently involves metastasis at diagnosis.
Our previous research has demonstrated that CCR7 plays a key role in regulating SCCHN metastasis, and this process involves several molecules, such as PI3K/cdc42, pyk2, and Src.
In this study, the goals are to identify whether JAK2/STAT3 also participates in CCR7’s signal network, its relationship with other signal pathways, and its role in SCCHN cell invasion and migration.
The results showed that stimulation of CCL19 could induce JAK2/STAT3 phosphorylation, which can be blocked by Src and pyk2 inhibitors.
After activation, STAT3 was able to promote low expression of E-cadherin and had no effect on vimentin.
This JAk2/STAT3 pathway not only mediated CCR7-induced cell migration but also mediated invasion speed.
The immunohistochemistry results also showed that the phosphorylation of STAT3 was correlated with CCR7 expression in SCCHN, and CCR7 and STAT3 phosphorylation were all associated with lymph node metastasis.
In conclusion, JAk2/STAT3 plays a key role in CCR7 regulating SCCHN metastasis.
American Psychological Association (APA)
Liu, Fa-Yu& Safdar, Jawad& Li, Zhen-Ning& Fang, Qi-Gen& Zhang, Xu& Xu, Zhong-Fei…[et al.]. 2014. CCR7 Regulates Cell Migration and Invasion through JAK2STAT3 in Metastatic Squamous Cell Carcinoma of the Head and Neck. BioMed Research International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1016281
Modern Language Association (MLA)
Liu, Fa-Yu…[et al.]. CCR7 Regulates Cell Migration and Invasion through JAK2STAT3 in Metastatic Squamous Cell Carcinoma of the Head and Neck. BioMed Research International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1016281
American Medical Association (AMA)
Liu, Fa-Yu& Safdar, Jawad& Li, Zhen-Ning& Fang, Qi-Gen& Zhang, Xu& Xu, Zhong-Fei…[et al.]. CCR7 Regulates Cell Migration and Invasion through JAK2STAT3 in Metastatic Squamous Cell Carcinoma of the Head and Neck. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1016281
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1016281