Radiation Oncology In Vitro: Trends to Improve Radiotherapy through Molecular Targets
Joint Authors
Feofanova, Natália
Geraldo, Jony Marques
Andrade, Lídia Maria de
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-15
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Much has been investigated to improve the beneficial effects of radiotherapy especially in that case where radioresistant behavior is observed.
Beyond simple identification of resistant phenotype the discovery and development of specific molecular targets have demonstrated therapeutic potential in cancer treatment including radiotherapy.
Alterations on transduction signaling pathway related with MAPK cascade are the main axis in cancer cellular proliferation even as cell migration and invasiveness in irradiated tumor cell lines; then, for that reason, more studies are in course focusing on, among others, DNA damage enhancement, apoptosis stimulation, and growth factors receptor blockages, showing promising in vitro results highlighting molecular targets associated with ionizing radiation as a new radiotherapy strategy to improve clinical outcome.
In this review we discuss some of the main molecular targets related with tumor cell proliferation and migration as well as their potential contributions to radiation oncology improvements.
American Psychological Association (APA)
Feofanova, Natália& Geraldo, Jony Marques& Andrade, Lídia Maria de. 2014. Radiation Oncology In Vitro: Trends to Improve Radiotherapy through Molecular Targets. BioMed Research International،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1016300
Modern Language Association (MLA)
Feofanova, Natália…[et al.]. Radiation Oncology In Vitro: Trends to Improve Radiotherapy through Molecular Targets. BioMed Research International No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-1016300
American Medical Association (AMA)
Feofanova, Natália& Geraldo, Jony Marques& Andrade, Lídia Maria de. Radiation Oncology In Vitro: Trends to Improve Radiotherapy through Molecular Targets. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1016300
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1016300