![](/images/graphics-bg.png)
The Effect of Multiwalled Carbon Nanotubes on Hepatotoxicity of Cd2+ in Accumulated Cadmium-Metallothione in Mice
Joint Authors
Wei, Qi
Juanjuan, Bi
Longlong, Tian
Zhan, Li
Peng, Liu
Wangsuo, Wu
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-02
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The effects of oxidized multiwalled carbon nanotubes (oMWCNTs) on the behavior and hepatotoxicity of Cd2+ in accumulated cadmium-metallothionein mice were investigated.
The results indicated that, after exposure of oMWCNTs to normal mice, oMWCNTs could not induce the liver to produce metallothionein (MT).
When exposing Cd-MT mouse to different doses of oMWCNTs oMWCNTs could cause Cd2+ release from the accumulated Cd-MT; subsequently, one part of the free Cd2+ was eliminated with blood circulation; the other part adsorbed by oMWCNTs would remain in the tissues together with oMWCNTs.
The results of the activities changes of alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TB), and blood urea nitrogen (BUN) in plasma showed that the hepatotoxicity of coexposure was lower than that of single exposure, and the hepatotoxicity and accumulation of oMWCNTs in livers depended strongly on the exposure dosage of oMWCNTs.
The histology of liver and kidney tissue also confirmed the previous results.
Therefore, the author inferred that MT could be connected with oMWCNTs to reduce their hepatotoxicity, but the detailed mechanism needs to be further studied.
American Psychological Association (APA)
Wei, Qi& Juanjuan, Bi& Longlong, Tian& Zhan, Li& Peng, Liu& Wangsuo, Wu. 2014. The Effect of Multiwalled Carbon Nanotubes on Hepatotoxicity of Cd2+ in Accumulated Cadmium-Metallothione in Mice. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1016303
Modern Language Association (MLA)
Wei, Qi…[et al.]. The Effect of Multiwalled Carbon Nanotubes on Hepatotoxicity of Cd2+ in Accumulated Cadmium-Metallothione in Mice. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1016303
American Medical Association (AMA)
Wei, Qi& Juanjuan, Bi& Longlong, Tian& Zhan, Li& Peng, Liu& Wangsuo, Wu. The Effect of Multiwalled Carbon Nanotubes on Hepatotoxicity of Cd2+ in Accumulated Cadmium-Metallothione in Mice. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1016303
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1016303