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Identification of Chemokines and Growth Factors in Proliferative Diabetic Retinopathy Vitreous
Joint Authors
Dai, Ying
Wu, Zhifeng
Wang, Feng
Zhang, Zhengwei
Yu, Mengxi
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-10-27
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Associations were investigated between levels of chemokines and growth factors in the vitreous and proliferative diabetic retinopathy (PDR).
Enrolled were 58 patients (58 eyes) requiring pars plana vitrectomy (PPV), with PDR ( n = 32 , none with traction retinal detachment) or not (non-PDR).
In the latter, 16 had macular hole (MH) and 10 had epiretinal membrane (ERM).
With a multiplex bead immunoassay, levels of 11 chemokines and growth factors were measured from the undiluted vitreous sample from each patient.
In the non-PDR eyes, the levels of the 11 chemokines and growth factors tested were similar between patients with MH and those with ERM.
However, the levels of all 11 were significantly higher in the PDR eyes relative to the non-PDR; CCL17, CCL19, and TGFβ3 were markedly upregulated and have not been investigated in PDR previously.
The significantly higher levels of CCL4 and CCL11 in PDR contradict the results of previous reports.
Based on Spearman’s nonparametric test, moderate-to-strong correlations were found between VEGF and other mediators.
Our results indicate that these chemokines and growth factors could be candidates for research into targeted therapies applied either singly or in combination with anti-VEGF drugs for the treatment of PDR.
American Psychological Association (APA)
Dai, Ying& Wu, Zhifeng& Wang, Feng& Zhang, Zhengwei& Yu, Mengxi. 2014. Identification of Chemokines and Growth Factors in Proliferative Diabetic Retinopathy Vitreous. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1016317
Modern Language Association (MLA)
Dai, Ying…[et al.]. Identification of Chemokines and Growth Factors in Proliferative Diabetic Retinopathy Vitreous. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1016317
American Medical Association (AMA)
Dai, Ying& Wu, Zhifeng& Wang, Feng& Zhang, Zhengwei& Yu, Mengxi. Identification of Chemokines and Growth Factors in Proliferative Diabetic Retinopathy Vitreous. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1016317
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1016317