Molecular Chaperone Dysfunction in Neurodegenerative Diseases and Effects of Curcumin
Joint Authors
Maiti, Panchanan
Manna, Jayeeta
Veleri, Shobi
Frautschy, Sally
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-10-19
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
The intra- and extracellular accumulation of misfolded and aggregated amyloid proteins is a common feature in several neurodegenerative diseases, which is thought to play a major role in disease severity and progression.
The principal machineries maintaining proteostasis are the ubiquitin proteasomal and lysosomal autophagy systems, where heat shock proteins play a crucial role.
Many protein aggregates are degraded by the lysosomes, depending on aggregate size, peptide sequence, and degree of misfolding, while others are selectively tagged for removal by heat shock proteins and degraded by either the proteasome or phagosomes.
These systems are compromised in different neurodegenerative diseases.
Therefore, developing novel targets and classes of therapeutic drugs, which can reduce aggregates and maintain proteostasis in the brains of neurodegenerative models, is vital.
Natural products that can modulate heat shock proteins/proteosomal pathway are considered promising for treating neurodegenerative diseases.
Here we discuss the current knowledge on the role of HSPs in protein misfolding diseases and knowledge gained from animal models of Alzheimer’s disease, tauopathies, and Huntington’s diseases.
Further, we discuss the emerging treatment regimens for these diseases using natural products, like curcumin, which can augment expression or function of heat shock proteins in the cell.
American Psychological Association (APA)
Maiti, Panchanan& Manna, Jayeeta& Veleri, Shobi& Frautschy, Sally. 2014. Molecular Chaperone Dysfunction in Neurodegenerative Diseases and Effects of Curcumin. BioMed Research International،Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-1016323
Modern Language Association (MLA)
Maiti, Panchanan…[et al.]. Molecular Chaperone Dysfunction in Neurodegenerative Diseases and Effects of Curcumin. BioMed Research International No. 2014 (2014), pp.1-14.
https://search.emarefa.net/detail/BIM-1016323
American Medical Association (AMA)
Maiti, Panchanan& Manna, Jayeeta& Veleri, Shobi& Frautschy, Sally. Molecular Chaperone Dysfunction in Neurodegenerative Diseases and Effects of Curcumin. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-1016323
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1016323