Analgesic and Anti-Inflammatory Activities of Leaf Extract of Mallotus repandus (Willd.) Muell. Arg.
Joint Authors
Hasan, Md. Mahadi
Uddin, Nizam
Hasan, Md. Rakib
Islam, A. F. M. Mahmudul
Hossain, Md. Monir
Rahman, Akib Bin
Hossain, Md. Sazzad
Chowdhury, Ishtiaque Ahmed
Rana, Md. Sohel
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-12-31
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
In folk medicine Mallotus repandus (Willd.) Muell.
Arg.
is used to treat muscle pain, itching, fever, rheumatic arthritis, snake bite, hepatitis, and liver cirrhosis.
This study aimed to evaluate the antinociceptive as well as the anti-inflammatory activities of the methanol extract of leaf.
The leaves were extracted with methanol following hot extraction and tested for the presence of phytochemical constituents.
Analgesic and anti-inflammatory activities were evaluated using acetic acid induced writhing test, xylene induced ear edema, cotton pellet induced granuloma, and tail immersion methods at doses of 500, 1000, and 2000 mg/kg body weight.
The presence of flavonoids, saponins, and tannins was identified in the extract.
The extract exhibited considerable antinociceptive and anti-inflammatory activities against four classical models of pain.
In acetic acid induced writhing, xylene induced ear edema, and cotton pellet granuloma models, the extract revealed dose dependent activity.
Additionally, it increased latency time in tail immersion model.
It can be concluded that M.
repandus possesses significant antinociceptive potential.
These findings suggest that this plant can be used as a potential source of new antinociceptive and anti-inflammatory candidates.
The activity of methanol extract is most likely mediated through central and peripheral inhibitory mechanisms.
This study justified the traditional use of leaf part of this plant.
American Psychological Association (APA)
Hasan, Md. Mahadi& Uddin, Nizam& Hasan, Md. Rakib& Islam, A. F. M. Mahmudul& Hossain, Md. Monir& Rahman, Akib Bin…[et al.]. 2014. Analgesic and Anti-Inflammatory Activities of Leaf Extract of Mallotus repandus (Willd.) Muell. Arg.. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1016351
Modern Language Association (MLA)
Hasan, Md. Mahadi…[et al.]. Analgesic and Anti-Inflammatory Activities of Leaf Extract of Mallotus repandus (Willd.) Muell. Arg.. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1016351
American Medical Association (AMA)
Hasan, Md. Mahadi& Uddin, Nizam& Hasan, Md. Rakib& Islam, A. F. M. Mahmudul& Hossain, Md. Monir& Rahman, Akib Bin…[et al.]. Analgesic and Anti-Inflammatory Activities of Leaf Extract of Mallotus repandus (Willd.) Muell. Arg.. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1016351
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1016351