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Systemic Treatment with Strontium Ranelate Accelerates the Filling of a Bone Defect and Improves the Material Level Properties of the Healing Bone
Joint Authors
Ammann, Patrick
Zacchetti, Giovanna
Dayer, Romain
Rizzoli, René
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-10-07
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Rapid bone defect filling with normal bone is a challenge in orthopaedics and dentistry.
Strontium ranelate (SrRan) has been shown to in vitro decrease bone resorption and increase bone formation, and represents a potential agent with the capacity to accelerate bone defect filling.
In this study, bone tibial defects of 2.5 mm in diameter were created in 6-month-old female rats orally fed SrRan (625 mg/kg/d; 5/7 days) or vehicle for 4, 8, or 12 weeks (10 rats per group per time point) from the time of surgery.
Tibias were removed.
Micro-architecture was determined by micro-computed tomography (µCT) and material level properties by nanoindentation analysis.
µCT analysis showed that SrRan administration significantly improved microarchitecture of trabecular bone growing into the defect after 8 and 12 weeks of treatment compared to vehicle.
SrRan treatment also accelerated the growth of cortical bone over the defect, but with different kinetics compared to trabecular bone, as the effects were already significant after 4 weeks.
Nanoindentation analysis demonstrated that SrRan treatment significantly increased material level properties of both trabecular bone and cortical bone filling the defect compared to vehicle.
SrRan accelerates the filling of bone defect by improving cortical and trabecular bone microarchitecture both quantitatively and qualitatively.
American Psychological Association (APA)
Zacchetti, Giovanna& Dayer, Romain& Rizzoli, René& Ammann, Patrick. 2014. Systemic Treatment with Strontium Ranelate Accelerates the Filling of a Bone Defect and Improves the Material Level Properties of the Healing Bone. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1016363
Modern Language Association (MLA)
Zacchetti, Giovanna…[et al.]. Systemic Treatment with Strontium Ranelate Accelerates the Filling of a Bone Defect and Improves the Material Level Properties of the Healing Bone. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1016363
American Medical Association (AMA)
Zacchetti, Giovanna& Dayer, Romain& Rizzoli, René& Ammann, Patrick. Systemic Treatment with Strontium Ranelate Accelerates the Filling of a Bone Defect and Improves the Material Level Properties of the Healing Bone. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1016363
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1016363