Understanding Host-Adherent-Invasive Escherichia coli Interaction in Crohn’s Disease: Opening Up New Therapeutic Strategies
Joint Authors
Agus, Allison
Massier, Sébastien
Darfeuille-Michaud, Arlette
Billard, Elisabeth
Barnich, Nicolas
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-12-15
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
A trillion of microorganisms colonize the mammalian intestine.
Most of them have coevolved with the host in a symbiotic relationship and some of them have developed strategies to promote their replication in the presence of competing microbiota.
Recent evidence suggests that perturbation of the microbial community favors the emergence of opportunistic pathogens, in particular adherent-invasive Escherichia coli (AIEC) that can increase incidence and severity of gut inflammation in the context of Crohn’s disease (CD).
This review will report the importance of AIEC as triggers of intestinal inflammation, focusing on their impact on epithelial barrier function and stimulation of mucosal inflammation.
Beyond manipulation of immune response, restoration of gut microbiota as a new treatment option for CD patients will be discussed.
American Psychological Association (APA)
Agus, Allison& Massier, Sébastien& Darfeuille-Michaud, Arlette& Billard, Elisabeth& Barnich, Nicolas. 2014. Understanding Host-Adherent-Invasive Escherichia coli Interaction in Crohn’s Disease: Opening Up New Therapeutic Strategies. BioMed Research International،Vol. 2014, no. 2014, pp.1-16.
https://search.emarefa.net/detail/BIM-1016368
Modern Language Association (MLA)
Agus, Allison…[et al.]. Understanding Host-Adherent-Invasive Escherichia coli Interaction in Crohn’s Disease: Opening Up New Therapeutic Strategies. BioMed Research International No. 2014 (2014), pp.1-16.
https://search.emarefa.net/detail/BIM-1016368
American Medical Association (AMA)
Agus, Allison& Massier, Sébastien& Darfeuille-Michaud, Arlette& Billard, Elisabeth& Barnich, Nicolas. Understanding Host-Adherent-Invasive Escherichia coli Interaction in Crohn’s Disease: Opening Up New Therapeutic Strategies. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-16.
https://search.emarefa.net/detail/BIM-1016368
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1016368