Chinese Herbs Containing Aristolochic Acid Associated with Renal Failure and Urothelial Carcinoma: A Review from Epidemiologic Observations to Causal Inference
Joint Authors
Wang, Jung-Der
Yang, Hsiao-Yu
Chen, Pau-Chung
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-27
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Herbal remedies containing aristolochic acid (AA) have been designated to be a strong carcinogen.
This review summarizes major epidemiologic evidence to argue for the causal association between AA exposure and urothelial carcinoma as well as nephropathy.
The exposure scenarios include the following: Belgian women taking slimming pills containing single material Guang Fang Ji, consumptions of mixtures of Chinese herbal products in the general population and patients with chronic renal failure in Taiwan, occupational exposure in Chinese herbalists, and food contamination in farming villages in valleys of the Danube River.
Such an association is corroborated by detecting specific DNA adducts in the tumor tissue removed from affected patients.
Preventive actions of banning such use and education to the healthcare professionals and public are necessary for the safety of herbal remedies.
American Psychological Association (APA)
Yang, Hsiao-Yu& Chen, Pau-Chung& Wang, Jung-Der. 2014. Chinese Herbs Containing Aristolochic Acid Associated with Renal Failure and Urothelial Carcinoma: A Review from Epidemiologic Observations to Causal Inference. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1016370
Modern Language Association (MLA)
Yang, Hsiao-Yu…[et al.]. Chinese Herbs Containing Aristolochic Acid Associated with Renal Failure and Urothelial Carcinoma: A Review from Epidemiologic Observations to Causal Inference. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1016370
American Medical Association (AMA)
Yang, Hsiao-Yu& Chen, Pau-Chung& Wang, Jung-Der. Chinese Herbs Containing Aristolochic Acid Associated with Renal Failure and Urothelial Carcinoma: A Review from Epidemiologic Observations to Causal Inference. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1016370
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1016370