![](/images/graphics-bg.png)
Importance of pH Homeostasis in Metabolic Health and Diseases: Crucial Role of Membrane Proton Transport
Joint Authors
Marunaka, Yoshinori
Aoi, Wataru
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-11
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Protons dissociated from organic acids in cells are partly buffered.
If not, they are transported to the extracellular fluid through the plasma membrane and buffered in circulation or excreted in urine and expiration gas.
Several transporters including monocarboxylate transporters and Na+/H+ exchanger play an important role in uptake and output of protons across plasma membranes in cells of metabolic tissues including skeletal muscle and the liver.
They also contribute to maintenance of the physiological pH of body fluid.
Therefore, impairment of these transporters causes dysfunction of cells, diseases, and a decrease in physical performance associated with abnormal pH.
Additionally, it is known that fluid pH in the interstitial space of metabolic tissues is easily changed due to little pH buffering capacitance in interstitial fluids and a reduction in the interstitial fluid pH may mediate the onset of insulin resistance unlike blood containing pH buffers such as Hb (hemoglobin) and albumin.
In contrast, habitual exercise and dietary intervention regulate expression/activity of transporters and maintain body fluid pH, which could partly explain the positive effect of healthy lifestyle on disease prognosis.
American Psychological Association (APA)
Aoi, Wataru& Marunaka, Yoshinori. 2014. Importance of pH Homeostasis in Metabolic Health and Diseases: Crucial Role of Membrane Proton Transport. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1016386
Modern Language Association (MLA)
Aoi, Wataru& Marunaka, Yoshinori. Importance of pH Homeostasis in Metabolic Health and Diseases: Crucial Role of Membrane Proton Transport. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1016386
American Medical Association (AMA)
Aoi, Wataru& Marunaka, Yoshinori. Importance of pH Homeostasis in Metabolic Health and Diseases: Crucial Role of Membrane Proton Transport. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1016386
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1016386