The Relationship between Helicobacter pylori and Beta-2 Microglobulin in Humans

Abstract EN

H.

pylori is related to various gastrointestinal diseases.

β 2 Microglobulin ( β 2 M) is an intrinsic element of major histocompatibility complex (MHC I).

Serum β 2 M level may increase in inflammatory states.

The aim of current study is to evaluate the relationship between β 2 M and H.

pylori bearing CagA strains.

Methods.

H.

pylori status was determined by histopathology of samples taken from stomach.

CagA status and β 2 M level were measured from blood samples of patients.

Eradication therapy was administered to the patients with H.

pylori infection.

β 2 Microglobulin levels were measured before and after treatment.

Results.

35 (29.2%) H.

pylori(−) patients and 85 (70.8%) H.

pylori (+) patients were included in the study.

There were 52 (43.3%) patients with CagA negative and 33 (27.5%) patients with CagA positive H.

pylori infection.

The mean serum β 2 M level was 1.83 mg/L in H.

pylori (−) group, 1.76 mg/L in H.

pylori (+) CagA (−) group, and 1.93 mg/L in H.

pylori and CagA (+) group ( P > 0.05 ).

Serum β 2 M levels (1.82 versus 1.64 mg/L P < 0.05 ) were decreased after eradication.

Conclusion.

H.

pylori and CagA status did not affect β 2 M level.

Relationship between low grade systematic inflammation and H.

pylori should be investigated to find out new predictors for diseases associated with inflammation.