Activation of the AT1RHIF-1αACE Axis Mediates Angiotensin II-Induced VEGF Synthesis in Mesenchymal Stem Cells
Joint Authors
Liu, Chao
Zhang, Jing-Wen
Hu, Liang
Song, Yi-Chen
Zhou, Lu
Fan, Yue
Zhu, Hong-Yi
Wang, Yu
Li, Qing-Ping
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-10-20
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
A local renin-angiotensin system (RAS) is expressed in mesenchymal stem cells (MSCs) and regulates stem cell function.
The local RAS influences the survival and tissue repairing ability of transplanted stem cells.
We have previously reported that angiotensin II (Ang II) pretreatment can significantly increase vascular endothelial growth factor (VEGF) synthesis in MSCs through the ERK1/2 and Akt pathways via the Ang II receptor type 1 (AT1R).
However, the role of angiotensin-converting enzyme (ACE) has not been clarified.
Furthermore, whether Ang II pretreatment activates hypoxia-inducible factor-1α (HIF-1α) in MSCs has not been elucidated.
Our data show that both ACE and HIF-1α are involved in promoting VEGF expression in MSCs, and that both are upregulated by Ang II stimulation.
The upregulation of ACE appeared after the rapid degradation of exogenous Ang II, and led to the formation of endogenous Ang II.
On the other hand, the ACE inhibitor, captopril, attenuated Ang II-enhanced HIF-1α upregulation, while HIF-1α suppression markedly attenuated ACE expression.
This interesting finding suggests an interaction between ACE and HIF-1α.
We conclude that Ang II pretreatment, as a trigger, activated the AT1R/HIF-1α/ACE axis that then mediated Ang II-induced VEGF synthesis in MSCs.
American Psychological Association (APA)
Liu, Chao& Zhang, Jing-Wen& Hu, Liang& Song, Yi-Chen& Zhou, Lu& Fan, Yue…[et al.]. 2014. Activation of the AT1RHIF-1αACE Axis Mediates Angiotensin II-Induced VEGF Synthesis in Mesenchymal Stem Cells. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1016408
Modern Language Association (MLA)
Liu, Chao…[et al.]. Activation of the AT1RHIF-1αACE Axis Mediates Angiotensin II-Induced VEGF Synthesis in Mesenchymal Stem Cells. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1016408
American Medical Association (AMA)
Liu, Chao& Zhang, Jing-Wen& Hu, Liang& Song, Yi-Chen& Zhou, Lu& Fan, Yue…[et al.]. Activation of the AT1RHIF-1αACE Axis Mediates Angiotensin II-Induced VEGF Synthesis in Mesenchymal Stem Cells. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1016408
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1016408