Coapplication of Lidocaine and Membrane-Impermeable Lidocaine Derivative QX-222 Produces Divergent Effects on Evoked and Spontaneous Nociceptive Behaviors in Mice
Joint Authors
Hu, Si-Ping
Zhao, Jing-Jing
Wang, Wei-Xing
Liu, Yang
Wu, He-Fen
Chen, Chao
Yu, Liang
Gui, Jing-Bing
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-11-24
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The present study was aimed at investigating the analgesic properties of a combination of lidocaine and QX-222 and its effects on evoked pain behavior (complete Freund’s adjuvant-induced allodynia and hyperalgesia in inflammatory condition) and spontaneous pain behavior (formalin-induced acute pain) in mice.
Drugs were injected adjacent to sciatic nerve or into plantar.
Motor function, thermal withdrawal latency, mechanical withdrawal threshold, and licking/biting were evaluated by behavioral tests.
A combination of lidocaine and QX-222 adjacent sciatic nerve injection produced the long-lasting sensory-specific nerve block, and intraplantar injection inhibited spontaneous pain in the formalin-treated mice but did not detectably attenuated hyperalgesia and allodynia in the complete Freund’s adjuvant- (CFA-) treated mice.
Our results suggest that a combination of lidocaine and QX-222 achieves a long-lasting differential block (sensory selective) and produces divergent effects on evoked and spontaneous pain behaviors in mice.
American Psychological Association (APA)
Hu, Si-Ping& Zhao, Jing-Jing& Wang, Wei-Xing& Liu, Yang& Wu, He-Fen& Chen, Chao…[et al.]. 2014. Coapplication of Lidocaine and Membrane-Impermeable Lidocaine Derivative QX-222 Produces Divergent Effects on Evoked and Spontaneous Nociceptive Behaviors in Mice. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1016410
Modern Language Association (MLA)
Hu, Si-Ping…[et al.]. Coapplication of Lidocaine and Membrane-Impermeable Lidocaine Derivative QX-222 Produces Divergent Effects on Evoked and Spontaneous Nociceptive Behaviors in Mice. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1016410
American Medical Association (AMA)
Hu, Si-Ping& Zhao, Jing-Jing& Wang, Wei-Xing& Liu, Yang& Wu, He-Fen& Chen, Chao…[et al.]. Coapplication of Lidocaine and Membrane-Impermeable Lidocaine Derivative QX-222 Produces Divergent Effects on Evoked and Spontaneous Nociceptive Behaviors in Mice. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1016410
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1016410