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Saccharin Sulfonamides as Inhibitors of Carbonic Anhydrases I, II, VII, XII, and XIII
Joint Authors
Matulis, Daumantas
Morkūnaitė, Vaida
Baranauskienė, Lina
Zubrienė, Asta
Kairys, Visvaldas
Ivanova, Jekaterina
Trapencieris, Pēteris
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-03
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
A series of modified saccharin sulfonamides have been designed as carbonic anhydrase (CA) inhibitors and synthesized.
Their binding to CA isoforms I, II, VII, XII, and XIII was measured by the fluorescent thermal shift assay (FTSA) and isothermal titration calorimetry (ITC).
Saccharin bound the CAs weakly, exhibiting the affinities of 1–10 mM for four CAs except CA I where binding could not be detected.
Several sulfonamide-bearing saccharines exhibited strong affinities of 1–10 nM towards particular CA isoforms.
The functional group binding Gibbs free energy additivity maps are presented which may provide insights into the design of compounds with increased affinity towards selected CAs.
American Psychological Association (APA)
Morkūnaitė, Vaida& Baranauskienė, Lina& Zubrienė, Asta& Kairys, Visvaldas& Ivanova, Jekaterina& Trapencieris, Pēteris…[et al.]. 2014. Saccharin Sulfonamides as Inhibitors of Carbonic Anhydrases I, II, VII, XII, and XIII. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1016418
Modern Language Association (MLA)
Morkūnaitė, Vaida…[et al.]. Saccharin Sulfonamides as Inhibitors of Carbonic Anhydrases I, II, VII, XII, and XIII. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1016418
American Medical Association (AMA)
Morkūnaitė, Vaida& Baranauskienė, Lina& Zubrienė, Asta& Kairys, Visvaldas& Ivanova, Jekaterina& Trapencieris, Pēteris…[et al.]. Saccharin Sulfonamides as Inhibitors of Carbonic Anhydrases I, II, VII, XII, and XIII. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1016418
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1016418