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Perfusion in the Tissue Surrounding Pancreatic Cancer and the Patient’s Prognosis
Joint Authors
Chiba, Tsutomu
Nishikawa, Yoshihiro
Tsuji, Yoshihisa
Isoda, Hiroyoshi
Kodama, Yuzo
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-11
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The objective was to investigate the relationship between prognosis in case of pancreatic cancer and perfusion in tissue surrounding pancreatic cancer using perfusion CT.
Methods.
We enrolled 17 patients diagnosed with inoperable pancreatic adenocarcinoma.
All patients were examined by perfusion CT and then underwent chemotherapy using gemcitabine.
The time density curve (TDC) of each CT pixel was analyzed to calculate area under the curve (AUC) and blood flow (BF) using a mathematical algorithm based on the single-compartment model.
To measure the AUC and BF of tumor (AUCT and BFT) and peritumoral tissue (AUCPTT and BFPTT), regions of interest were manually placed on the cancer and in pancreatic tissue within 10 mm of proximal pancreatic parenchyma.
Survival days from the date of perfusion CT were recorded.
Correlation between AUC or BF and survival days was assessed.
Results.
We found a significant correlation between AUCPTT or BFPTT and survival days (P=0.04 or 0.0005).
Higher AUCPTT or BFPTT values were associated with shorter survival.
We found no significant correlation between AUCT or BFT and survival.
Conclusions.
Our results suggest that assessments of perfusion in pancreatic tissue within 10 mm of proximal pancreatic parenchyma may be useful in predicting prognosis.
American Psychological Association (APA)
Nishikawa, Yoshihiro& Tsuji, Yoshihisa& Isoda, Hiroyoshi& Kodama, Yuzo& Chiba, Tsutomu. 2014. Perfusion in the Tissue Surrounding Pancreatic Cancer and the Patient’s Prognosis. BioMed Research International،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1016425
Modern Language Association (MLA)
Nishikawa, Yoshihiro…[et al.]. Perfusion in the Tissue Surrounding Pancreatic Cancer and the Patient’s Prognosis. BioMed Research International No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1016425
American Medical Association (AMA)
Nishikawa, Yoshihiro& Tsuji, Yoshihisa& Isoda, Hiroyoshi& Kodama, Yuzo& Chiba, Tsutomu. Perfusion in the Tissue Surrounding Pancreatic Cancer and the Patient’s Prognosis. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1016425
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1016425