Collagen-Glycosaminoglycan Matrix Implantation Promotes Angiogenesis following Surgical Brain Trauma
Joint Authors
Huang, Kuo-Feng
Hsu, Wei-Cherng
Hsiao, Jong-Kai
Chen, Gunng-Shinng
Wang, Jia-Yi
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-25
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Surgical brain injury (SBI) is unavoidable during many neurosurgical procedures intrinsically linked to postoperative neurological deficits.
We have previously demonstrated that implantation of collagen glycosaminoglycan (CG) following surgical brain injury could significantly promote functional recovery and neurogenesis.
In this study we further hypothesized that this scaffold may provide a microenvironment by promoting angiogenesis to favor neurogenesis and subsequent functional recovery.
Using the rodent model of surgical brain injury as we previously established, we divided Sprague-Dawley male rats (weighting 300–350 g) into three groups: (1) sham (2) surgical injury with a lesion (L), and (3) L with CG matrix implantation (L + CG).
Our results demonstrated that L + CG group showed a statistically significant increase in the density of vascular endothelial cells and blood vessels over time.
In addition, tissue concentrations of angiogenic growth factors (such as VEGF, FGF2, and PDGF) significantly increased in L + CG group.
These results suggest that implantation of a CG scaffold can promote vascularization accompanied by neurogenesis.
This opens prospects for use of CG scaffolds in conditions such as brain injury including trauma and ischemia.
American Psychological Association (APA)
Huang, Kuo-Feng& Hsu, Wei-Cherng& Hsiao, Jong-Kai& Chen, Gunng-Shinng& Wang, Jia-Yi. 2014. Collagen-Glycosaminoglycan Matrix Implantation Promotes Angiogenesis following Surgical Brain Trauma. BioMed Research International،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1016439
Modern Language Association (MLA)
Huang, Kuo-Feng…[et al.]. Collagen-Glycosaminoglycan Matrix Implantation Promotes Angiogenesis following Surgical Brain Trauma. BioMed Research International No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-1016439
American Medical Association (AMA)
Huang, Kuo-Feng& Hsu, Wei-Cherng& Hsiao, Jong-Kai& Chen, Gunng-Shinng& Wang, Jia-Yi. Collagen-Glycosaminoglycan Matrix Implantation Promotes Angiogenesis following Surgical Brain Trauma. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1016439
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1016439