Liver Autophagy in Anorexia Nervosa and Acute Liver Injury
Joint Authors
Kheloufi, Marouane
Boulanger, Chantal M.
Durand, François
Rautou, Pierre-Emmanuel
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-27
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Autophagy, a lysosomal catabolic pathway for long-lived proteins and damaged organelles, is crucial for cell homeostasis, and survival under stressful conditions.
During starvation, autophagy is induced in numerous organisms ranging from yeast to mammals, and promotes survival by supplying nutrients and energy.
In the early neonatal period, when transplacental nutrients supply is interrupted, starvation-induced autophagy is crucial for neonates’ survival.
In adult animals, autophagy provides amino acids and participates in glucose metabolism following starvation.
In patients with anorexia nervosa, autophagy appears initially protective, allowing cells to copes with nutrient deprivation.
However, when starvation is critically prolonged and when body mass index reaches 13 kg/m2 or lower, acute liver insufficiency occurs with features of autophagic cell death, which can be observed by electron microscopy analysis of liver biopsy samples.
In acetaminophen overdose, a classic cause of severe liver injury, autophagy is induced as a protective mechanism.
Pharmacological enhancement of autophagy protects against acetaminophen-induced necrosis.
Autophagy is also activated as a rescue mechanism in response to Efavirenz-induced mitochondrial dysfunction.
However, Efavirenz overdose blocks autophagy leading to liver cell death.
In conclusion, in acute liver injury, autophagy appears as a protective mechanism that can be however blocked or overwhelmed.
American Psychological Association (APA)
Kheloufi, Marouane& Boulanger, Chantal M.& Durand, François& Rautou, Pierre-Emmanuel. 2014. Liver Autophagy in Anorexia Nervosa and Acute Liver Injury. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1016496
Modern Language Association (MLA)
Kheloufi, Marouane…[et al.]. Liver Autophagy in Anorexia Nervosa and Acute Liver Injury. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1016496
American Medical Association (AMA)
Kheloufi, Marouane& Boulanger, Chantal M.& Durand, François& Rautou, Pierre-Emmanuel. Liver Autophagy in Anorexia Nervosa and Acute Liver Injury. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1016496
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1016496