From Pathways to Targets: Understanding the Mechanisms behind Polyglutamine Disease
Joint Authors
Weber, Jonasz Jeremiasz
Sowa, Anna Sergeevna
Binder, Tina
Hübener, Jeannette
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-22, 22 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-21
Country of Publication
Egypt
No. of Pages
22
Main Subjects
Abstract EN
The history of polyglutamine diseases dates back approximately 20 years to the discovery of a polyglutamine repeat in the androgen receptor of SBMA followed by the identification of similar expansion mutations in Huntington’s disease, SCA1, DRPLA, and the other spinocerebellar ataxias.
This common molecular feature of polyglutamine diseases suggests shared mechanisms in disease pathology and neurodegeneration of disease specific brain regions.
In this review, we discuss the main pathogenic pathways including proteolytic processing, nuclear shuttling and aggregation, mitochondrial dysfunction, and clearance of misfolded polyglutamine proteins and point out possible targets for treatment.
American Psychological Association (APA)
Weber, Jonasz Jeremiasz& Sowa, Anna Sergeevna& Binder, Tina& Hübener, Jeannette. 2014. From Pathways to Targets: Understanding the Mechanisms behind Polyglutamine Disease. BioMed Research International،Vol. 2014, no. 2014, pp.1-22.
https://search.emarefa.net/detail/BIM-1016498
Modern Language Association (MLA)
Weber, Jonasz Jeremiasz…[et al.]. From Pathways to Targets: Understanding the Mechanisms behind Polyglutamine Disease. BioMed Research International No. 2014 (2014), pp.1-22.
https://search.emarefa.net/detail/BIM-1016498
American Medical Association (AMA)
Weber, Jonasz Jeremiasz& Sowa, Anna Sergeevna& Binder, Tina& Hübener, Jeannette. From Pathways to Targets: Understanding the Mechanisms behind Polyglutamine Disease. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-22.
https://search.emarefa.net/detail/BIM-1016498
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1016498