Increased DJ-1 in Urine Exosome of Korean Males with Parkinson’s Disease
Joint Authors
Ho, Dong Hwan
Yi, Sanghak
Seo, Hyemyung
Son, Ilhong
Seol, Wongi
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-11-13
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Parkinson’s disease (PD) is a difficult disease to diagnose although it is the second most common neurodegenerative disease.
Recent studies show that exosome isolated from urine contains LRRK2 or DJ-1, proteins whose mutations cause PD.
To investigate a potential use for urine exosomes as a tool for PD diagnosis, we compared levels of LRRK2, α-synuclein, and DJ-1 in urine exosomes isolated from Korean PD patients and non-PD controls.
LRRK2 and DJ-1, but not α-synuclein, were detected in the urine exosome samples, as reported previously.
We initially could not detect any significant difference in these protein levels between the patient and the control groups.
However, when age, disease duration, L-dopa daily dose, and gender were considered as analytical parameters, LRRK2 and DJ-1 protein levels showed clear gender-dependent differences.
In addition, DJ-1 level was significantly higher (1.7-fold) in male patients with PD than that in male non-PD controls and increased in an age-dependent manner in male patients with PD.
Our observation might provide a clue to lead to a novel biomarker for PD diagnosis, at least in males.
American Psychological Association (APA)
Ho, Dong Hwan& Yi, Sanghak& Seo, Hyemyung& Son, Ilhong& Seol, Wongi. 2014. Increased DJ-1 in Urine Exosome of Korean Males with Parkinson’s Disease. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1016503
Modern Language Association (MLA)
Ho, Dong Hwan…[et al.]. Increased DJ-1 in Urine Exosome of Korean Males with Parkinson’s Disease. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1016503
American Medical Association (AMA)
Ho, Dong Hwan& Yi, Sanghak& Seo, Hyemyung& Son, Ilhong& Seol, Wongi. Increased DJ-1 in Urine Exosome of Korean Males with Parkinson’s Disease. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1016503
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1016503