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Comparison of Structural Architecture of HCV NS3 Genotype 1 versus Pakistani Genotype 3a
Joint Authors
Fatima, Kaneez
Azhar, Esam
Mathew, Shilu
Damanhouri, Ghazi
Qadri, Ishtiaq
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-10-21
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
This study described the structural characterization of Pakistani HCV NS3 GT3a in parallel with genotypes 1a and 1b NS3.
We investigated the role of amino acids and their interaction patterns in different HCV genotypes by crystallographic modeling.
Different softwares were used to study the interaction pattern, for example, CLCBIO sequence viewer, MODELLER, NMRCLUST, ERRAT score, and MODELLER.
Sixty models were produced and clustered into groups and the best model of PK-NCVI/Pk3a NS3 was selected and studied further to check the variability with other HCV NS3 genotypes.
This study will help in future to understand the structural architecture of HCV genome variability and to further define the conserved targets for antiviral agents.
American Psychological Association (APA)
Fatima, Kaneez& Azhar, Esam& Mathew, Shilu& Damanhouri, Ghazi& Qadri, Ishtiaq. 2014. Comparison of Structural Architecture of HCV NS3 Genotype 1 versus Pakistani Genotype 3a. BioMed Research International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1016536
Modern Language Association (MLA)
Fatima, Kaneez…[et al.]. Comparison of Structural Architecture of HCV NS3 Genotype 1 versus Pakistani Genotype 3a. BioMed Research International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1016536
American Medical Association (AMA)
Fatima, Kaneez& Azhar, Esam& Mathew, Shilu& Damanhouri, Ghazi& Qadri, Ishtiaq. Comparison of Structural Architecture of HCV NS3 Genotype 1 versus Pakistani Genotype 3a. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1016536
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1016536