Therapeutic Use of MicroRNAs in Lung Cancer
Joint Authors
Sozzi, Gabriella
Fortunato, Orazio
Boeri, Mattia
Verri, Carla
Moro, Massimo
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-16
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Lung cancer is a leading cause of cancer deaths worldwide.
Although the molecular pathways of lung cancer have been partly known, the high mortality rate is not markedly changed.
MicroRNAs (miRNAs) are small noncoding RNAs that actively modulate cell physiological processes as apoptosis, cell-cycle control, cell proliferation, DNA repair, and metabolism.
Several studies demonstrated that miRNAs are involved in the pathogenesis of lung diseases including lung cancer and they negatively regulate gene and protein expression by acting as oncogenes or tumor suppressors.
In this review we summarize the current knowledge on the role of miRNAs and their target genes in lung tumorigenesis and evaluate their potential use as therapeutic agents in lung cancer.
In particular, we describe methodological approaches such as inhibition of oncogenic miRNAs or replacement of tumor suppressor miRNAs, both in in vitro and in vivo assays.
Furthermore we discuss new strategies to achieve in vivo tissue specific delivery, potential off-target effects, and safety of miRNAs systemic delivery.
American Psychological Association (APA)
Fortunato, Orazio& Boeri, Mattia& Verri, Carla& Moro, Massimo& Sozzi, Gabriella. 2014. Therapeutic Use of MicroRNAs in Lung Cancer. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1016540
Modern Language Association (MLA)
Fortunato, Orazio…[et al.]. Therapeutic Use of MicroRNAs in Lung Cancer. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1016540
American Medical Association (AMA)
Fortunato, Orazio& Boeri, Mattia& Verri, Carla& Moro, Massimo& Sozzi, Gabriella. Therapeutic Use of MicroRNAs in Lung Cancer. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1016540
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1016540