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Alterations in Red Blood Cell Deformability during Storage: A Microfluidic Approach
Joint Authors
Cluitmans, Judith C. A.
Chokkalingam, Venkatachalam
Janssen, Arno M.
Brock, Roland
Huck, Wilhelm T. S.
Bosman, Giel J. C. G. M.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-10
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Red blood cells (RBCs) undergo extensive deformation when travelling through the microcapillaries.
Deformability, the combined result of properties of the membrane-cytoskeleton complex, the surface area-to-volume ratio, and the hemoglobin content, is a critical determinant of capillary blood flow.
During blood bank storage and in many pathophysiological conditions, RBC morphology changes, which has been suggested to be associated with decreased deformability and removal of RBC.
While various techniques provide information on the rheological properties of stored RBCs, their clinical significance is controversial.
We developed a microfluidic approach for evaluating RBC deformability in a physiologically meaningful and clinically significant manner.
Unlike other techniques, our method enables a high-throughput determination of changes in deformation capacity to provide statistically significant data, while providing morphological information at the single-cell level.
Our data show that, under conditions that closely mimic capillary dimensions and flow, the capacity to deform and the capacity to relax are not affected during storage in the blood bank.
Our data also show that altered cell morphology by itself does not necessarily affect deformability.
American Psychological Association (APA)
Cluitmans, Judith C. A.& Chokkalingam, Venkatachalam& Janssen, Arno M.& Brock, Roland& Huck, Wilhelm T. S.& Bosman, Giel J. C. G. M.. 2014. Alterations in Red Blood Cell Deformability during Storage: A Microfluidic Approach. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1016547
Modern Language Association (MLA)
Cluitmans, Judith C. A.…[et al.]. Alterations in Red Blood Cell Deformability during Storage: A Microfluidic Approach. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1016547
American Medical Association (AMA)
Cluitmans, Judith C. A.& Chokkalingam, Venkatachalam& Janssen, Arno M.& Brock, Roland& Huck, Wilhelm T. S.& Bosman, Giel J. C. G. M.. Alterations in Red Blood Cell Deformability during Storage: A Microfluidic Approach. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1016547
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1016547